ArticleJournal of acquired immune deficiency syndromes (1999)2013
Social network-based recruitment successfully reveals HIV-1 transmission networks among high-risk individuals in El Salvador.
Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- HIV Response Interventions that Integrate HIV Molecular Cluster and Social Network Analysis: A Systematic Review.AIDS and behavior · 2022Pooled it
- Use of HIV Recency Assays for HIV Incidence Estimation and Other Surveillance Use Cases: Systematic Review.JMIR public health and surveillance · 2022Pooled it
- Defining HIV-1 transmission clusters based on sequence data.AIDS (London, England) · 2017Pooled it
- A Systematic Review of Published Respondent-Driven Sampling Surveys Collecting Behavioral and Biologic Data.AIDS and behavior · 2016Pooled it
- Pooled it
- Social network isolation and cohesion and their association with HIV clustering among Black and Latino sexual minority men: implications for public health strategy.Scientific reports · 2026Article
- Dynamics of clustering rates in the Rhode Island HIV-1 epidemic.AIDS (London, England) · 2025Article
- Respondent-driven sampling is more efficient than facility-based strategies at identifying undiagnosed people who inject drugs living with HIV in India.Drug and alcohol dependence · 2023Article
- Integrated molecular and affiliation network analysis: Core-periphery social clustering is associated with HIV transmission patterns.Social networks · 2022Article
- Sexual health norms and communication patterns within the close social networks of men who have sex with men and transgender women in Lima, Peru: a 2017 cross-sectional study.BMC public health · 2021Article
- Genetic clustering analysis for HIV infection among MSM in Nigeria: implications for intervention.AIDS (London, England) · 2020Observational
- Phylogenetic analysis highlights the role of older people in the transmission of HIV-1 in Fuyang, Anhui Province, China.BMC infectious diseases · 2019Article
- In-depth Sampling of High-risk Populations to Characterize HIV Transmission Epidemics Among Young MSM Using PrEP in France and Quebec.Open forum infectious diseases · 2019Article
- Social Networks of Substance-Using Populations: Key Issues and Promising New Approaches for HIV.Current HIV/AIDS reports · 2019Review
- Molecular Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals in a Network-Based Intervention (Transmission Reduction Intervention Project): Phylogenetics Identify HIV-1-Infected Individuals With Social Links.The Journal of infectious diseases · 2018Article
- Comparison of Self-report to Biomarkers of Recent HIV Infection: Findings from the START Trial.AIDS and behavior · 2018Article
- Network Viral Load: A Critical Metric for HIV Elimination.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Short Communication: Lack of Support for Socially Connected HIV-1 Transmission Among Young Adult Black Men Who Have Sex with Men.AIDS research and human retroviruses · 2017Article
- Enhanced use of phylogenetic data to inform public health approaches to HIV among men who have sex with men.Sexual health · 2017Review
- Social and Genetic Networks of HIV-1 Transmission in New York City.PLoS pathogens · 2017Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveHIV in Central America is concentrated among certain groups such as men who have sex with men (MSM) and female sex workers (FSWs). We compared social recruitment chains and HIV transmission clusters from 699 MSM and 787 FSWs to better understand factors contributing to ongoing HIV transmission in El Salvador.
methodsPhylogenies were reconstructed using pol sequences from 119 HIV-positive individuals recruited by respondent-driven sampling (RDS) and compared with RDS chains in 3 cities in El Salvador. Transmission clusters with a mean pairwise genetic distance ≤ 0.015 and Bayesian posterior probabilities =1 were identified. Factors associated with cluster membership were evaluated among MSM.
resultsSequences from 34 (43%) MSM and 4 (10%) FSW grouped in 14 transmission clusters. Clusters were defined by risk group (12 MSM clusters) and geographic residence (only 1 spanned separate cities). In 4 MSM clusters (all n = 2), individuals were also members of the same RDS chain, but only 2 had members directly linked through recruitment. All large clusters (n ≥ 3) spanned >1 RDS chain. Among MSM, factors independently associated with cluster membership included recent infection by BED assay (P = 0.02), sex with stable male partners (P = 0.02), and sex with ≥ 3 male partners in the past year (P = 0.04).
conclusionsWe found few HIV transmissions corresponding directly with the social recruitment. However, we identified clustering in nearly one-half of MSM suggesting that RDS recruitment was indirectly but successfully uncovering transmission networks, particularly among recent infections. Interrogating RDS chains with phylogenetic analyses may help refine methods for identifying transmission clusters.
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