ArticleThe journal of nutrition, health & aging2013
Parathyroid hormone response to severe vitamin D deficiency is sex associated: an observational study of 571 hip fracture inpatients.
Article in The journal of nutrition, health & aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Gender differences between smoking and the risk of hip fracture.Journal of bone and mineral metabolism · 2024Pooled it
- The Phenotype of Bone Turnover in Patients with Fragility Hip Fracture: Experience in a Fracture Liaison Service Population.International journal of environmental research and public health · 2022Article
- Simultaneous hip and upper-limb fractures are associated with lower Geriatric Nutritional Index scores than isolated hip fractures: a cross-sectional study of 858 women.Aging clinical and experimental research · 2020Article
- Article
- Sex, Residence and Fish Intake Predict Vitamin D Status in Chinese Centenarians.The journal of nutrition, health & aging · 2019Article
- Vitamin D status and its predictors in New Zealand aged-care residents eligible for a government-funded universal vitamin D supplementation programme.Public health nutrition · 2016Article
- Parathyroid hormone response to two levels of vitamin D deficiency is associated with high risk of medical problems during hospitalization in patients with hip fracture.Journal of endocrinological investigation · 2015Article
- Parathyroid Hormone is Related to Dysplasia and a Higher Rate of Distal Colorectal Adenoma in Women but Not Men.Hormones & cancer · 2015Article
- A Study of the Applicability of GFR Evaluation Equations for an Elderly Chinese Population.The journal of nutrition, health & aging · 2015Article
- Muscle-bone and fat-bone interactions in regulating bone mass: do PTH and PTHrP play any role?Endocrine · 2014Review
- Poststroke hip fracture: prevalence, clinical characteristics, mineral-bone metabolism, outcomes, and gaps in prevention.Stroke research and treatment · 2013Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the association between sex and parathyroid hormone response to severe vitamin D deficiency after hip fracture.
designCross-sectional study.
settingRehabilitation hospital in Italy.
participants571 consecutive inpatients with hip fracture and severe vitamin D deficiency (serum 25-hydroxyvitamin D < 12ng/ml), without hypercalcemia or estimated glomerular filtration rate (GFR) < 15ml/min. MEASUREMENTS: In each patient we assessed PTH (by two-site chemiluminescent enzyme-labelled immunometric assay), 25-hydroxyvitamin D (by immunoenzymatic assay), albumin-adjusted total calcium, phosphate, magnesium, and creatinine 21.3 ± 6.1 (mean ± SD) days after fracture occurrence. Functional level was assessed using the Barthel index. PTH response to vitamin D deficiency was classified as either secondary hyperparathyroidism (serum PTH >75pg/ml) or functional hypoparathyroidism, i.e., inappropriate normal levels of PTH (≤75pg/ml).
resultsAmong the 571 patients, 336 (59%) had functional hypoparathyroidism, whereas 235 (41%) had secondary hyperparathyroidism. PTH status was significantly different between sexes (p=0.003): we found functional hypoparathyroidism in 61% of women and 43% of men (secondary hyperparathyroidism in 39% of women and 57% of men). The significance of the between-sex difference was maintained after adjustment for age, estimated GFR, phosphate, albumin-adjusted total calcium, albumin, Barthel index scores, 25-hydroxyvitamin D, and hip fracture type (either cervical or trochanteric). The adjusted odds ratio was 1.85 (95%CI from 1.09 to 3.13; p=0.023).
conclusionsData shows that PTH response to vitamin D deficiency was sex-associated following a fracture of the hip. The higher prevalence of secondary hyperparathyroidism may play a role in the known prognostic disadvantage found in hip-fracture men.
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