ArticleHypertension research : official journal of the Japanese Society of Hypertension2013
Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- The Impact of Glycaemic Variability on Vascular Dysfunction in Diabetes.Biomolecules · 2025Review
- Optimization for Simultaneous Determination of a Panel of Advanced Glycation End Products as Biomarkers for Metabolic Diseases.Journal of agricultural and food chemistry · 2025Article
- Article
- Natural and Synthetic Agents Targeting Reactive Carbonyl Species against Metabolic Syndrome.Molecules (Basel, Switzerland) · 2022Review
- Oxidative Stress and Hypertension.Circulation research · 2021Review
- A Comprehensive Review on Source, Types, Effects, Nanotechnology, Detection, and Therapeutic Management of Reactive Carbonyl Species Associated with Various Chronic Diseases.Antioxidants (Basel, Switzerland) · 2020Review
- Evidence of Blood and Muscle Redox Status Imbalance in Experimentally Induced Renal Insufficiency in a Rabbit Model.Oxidative medicine and cellular longevity · 2019Article
- Sodium bicarbonate loading limits tubular cast formation independent of glomerular injury and proteinuria in Dahl salt-sensitive rats.Clinical science (London, England : 1979) · 2018Article
- The Vascular-Renal Connection in Patients Hospitalized With Hypertensive Crisis: A Population-Based Study.Mayo Clinic proceedings. Innovations, quality & outcomes · 2018Article
- N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy.Scientific reports · 2017Article
- The effect of chronic renal failure on cardiac function: an experimental study with a rat model.Journal of echocardiography · 2016Article
- Implication of advanced glycation end products (Ages) and their receptor (Rage) on myocardial contractile and mitochondrial functions.Glycoconjugate journal · 2016Review
- Periostin expression induced by oxidative stress contributes to myocardial fibrosis in a rat model of high salt-induced hypertension.Molecular medicine reports · 2016Article
- Targeting Reactive Carbonyl Species with Natural Sequestering Agents.Molecules (Basel, Switzerland) · 2016Review
- Sex differences in the blood antioxidant defense system in juvenile rats with various genetic predispositions to hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Time course of cardiac inflammation during nitric oxide synthase inhibition in SHR: impact of prior transient ACE inhibition.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- TLR4 as a possible key regulator of pathological vascular remodeling by Ang II receptor activation.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Association between renal iron accumulation and renal interstitial fibrosis in a rat model of chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Possible therapeutic impact of the iron chelation on renal fibrosis.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One major precursor of carbonyl stress, methylglyoxal (MG), is elevated in the plasma of chronic kidney disease (CKD) patients, and this precursor contributes to the progression of vascular injury, hypertension and renal injury in diabetic nephropathy patients. This molecule induces salt-sensitive hypertension via a reactive oxygen species-mediated pathway. We examined the role of MG in the pathogenesis of hypertension and cardio-renal injury in Dahl salt-sensitive (Dahl S) rats, which is a rat model of CKD. Nine-week-old Dahl S rats were fed a 1% NaCl diet, and 1% MG was added to their drinking water for up to 12 weeks. Blood pressure and cardio-renal injuries were compared with rats treated with tap water alone. The angiotensin II receptor blocker (ARB), candesartan (10 mg kg(-1) day(-1)), was administered to MG Dahl S rats to determine the impact of this drug on the pathogenesis of MG-induced CKD. A progressive increase in systolic blood pressure was observed (123±1-148±5 mm Hg) after 12 weeks of MG administration. MG administration significantly increased urinary albumin excretion, glomerular sclerosis, tubular injury, myocardial collagen content and cardiac perivascular fibrosis. MG also enhanced the renal expression of Nɛ-carboxyethyl-lysine (an advanced glycation end product), 8-hydroxydeoxyguanosine (a marker of oxidative stress), macrophage (ED-1) positive cells (a marker of inflammation) and nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase activity. Candesartan treatment for 4 weeks significantly reduced these parameters. These results suggest that MG-induced hypertension and cardio-renal injury and increased inflammation and carbonyl and oxidative stress, which were partially preventable by an ARB.
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