ArticleDevelopment (Cambridge, England)2013
Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- The Drosophila histone methyltransferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiation.Development (Cambridge, England) · 2024Article
- ThebioRxiv : the preprint server for biology · 2024Article
- Histone H3K27 methylation-mediated repression ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.Developmental biology · 2021Review
- Single-cyst transcriptome analysis ofDevelopment (Cambridge, England) · 2020Article
- Heterochromatin Protein 1 (HP1) inhibits stem cell proliferation induced by ectopic activation of the Jak/STAT pathway in the Drosophila testis.Experimental cell research · 2019Article
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Enhancer of polycomb coordinates multiple signaling pathways to promote both cyst and germline stem cell differentiation in the Drosophila adult testis.PLoS genetics · 2017Article
- Cytokines in Male Fertility and Reproductive Pathologies: Immunoregulation and Beyond.Frontiers in endocrinology · 2017Review
- Estrogen, through estrogen receptor 1, regulates histone modifications and chromatin remodeling during spermatogenesis in adult rats.Epigenetics · 2017Article
- Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling.PLoS genetics · 2016Article
- Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity.Biology open · 2015Article
- Epigenetic regulation of germ cells-remember or forget?Current opinion in genetics & development · 2015Review
- A non-cell autonomous role of E(z) to prevent germ cells from turning on a somatic cell marker.Science (New York, N.Y.) · 2014Article
- Epigenetic regulation in adult stem cells and cancers.Cell & bioscience · 2013Article
- The nuclear lamina regulates germline stem cell niche organization via modulation of EGFR signaling.Cell stem cell · 2013Article
- Review
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4 authors at 2 institutions in 1 country.
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Abstract
Adult stem cells reside in microenvironments called niches, where they are regulated by both extrinsic cues, such as signaling from neighboring cells, and intrinsic factors, such as chromatin structure. Here we report that in the Drosophila testis niche an H3K27me3-specific histone demethylase encoded by Ubiquitously transcribed tetratricopeptide repeat gene on the X chromosome (dUTX) maintains active transcription of the Suppressor of cytokine signaling at 36E (Socs36E) gene by removing the repressive H3K27me3 modification near its transcription start site. Socs36E encodes an inhibitor of the Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling pathway. Whereas much is known about niche-to-stem cell signaling, such as the JAK-STAT signaling that is crucial for stem cell identity and activity, comparatively little is known about signaling from stem cells to the niche. Our results reveal that stem cells send feedback to niche cells to maintain the proper gene expression and architecture of the niche. We found that dUTX acts in cyst stem cells to maintain gene expression in hub cells through activating Socs36E transcription and preventing hyperactivation of JAK-STAT signaling. dUTX also acts in germline stem cells to maintain hub structure through regulating DE-Cadherin levels. Therefore, our findings provide new insights into how an epigenetic factor regulates crosstalk among different cell types within an endogenous stem cell niche, and shed light on the biological functions of a histone demethylase in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.