Evidence map›Paper›PMID 23364195›Full record

ReviewThe Journal of general virology2013

Recent developments in human immunodeficiency virus-1 latency research.

Chi Ngai Chan, Isabelle Dietrich, Margaret J Hosie, Brian J Willett

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of general virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  4. Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART.Proceedings of the National Academy of Sciences of the United States of America · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chi Ngai ChanMRC-University of Glasgow Centre for Virus Research, Bearsden Road, Glasgow G61 1QH, UK.
Isabelle DietrichMRC-University of Glasgow Centre for Virus Research, Bearsden Road, Glasgow G61 1QH, UK.
Margaret J HosieMRC-University of Glasgow Centre for Virus Research, Bearsden Road, Glasgow G61 1QH, UK.
Brian J WillettMRC-University of Glasgow Centre for Virus Research, Bearsden Road, Glasgow G61 1QH, UK.
MRC University of Glasgow Centre for Virus Research · GB

Funding

Biotechnology and Biological Sciences Research Council BB/D008425/1Medical Research Council G0300387Medical Research Council G0801822Wellcome Trust
6 · The paper itself

Abstract

Almost 30 years after its initial discovery, infection with the human immunodeficiency virus-1 (HIV-1) remains incurable and the virus persists due to reservoirs of latently infected CD4(+) memory T-cells and sanctuary sites within the infected individual where drug penetration is poor. Reactivating latent viruses has been a key strategy to completely eliminate the virus from the host, but many difficulties and unanswered questions remain. In this review, the latest developments in HIV-persistence and latency research are presented.

Indexed as

Virus LatencyAnti-HIV AgentsCD4-Positive T-LymphocytesHIV-1HIV InfectionsHumansModels, BiologicalVirus ActivationAnti-HIV Agents

Identifiers

PMID23364195
PMCPMC3709588
OpenAlexW2115371723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.