ArticlePediatric research2013
Hyperglycemia increases the risk of death in extremely preterm baboons.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Feasibility of automated insulin delivery guided by continuous glucose monitoring in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2020Trial
- Hyperglycemia and prematurity: a narrative review.Pediatric research · 2023Review
- Continuous Glucose Monitoring in Preterm Infants: The Role of Nutritional Management in Minimizing Glycemic Variability.Antioxidants (Basel, Switzerland) · 2022Article
- Structural Refinement of the Auditory Brainstem Neurons in Baboons During Perinatal Development.Frontiers in cellular neuroscience · 2021Article
- Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum.Brain sciences · 2020Article
- Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation.Diabetes · 2020Article
- Association of novel markers of liver disease with neonatal liver disease in premature baboons, Papio sp.PloS one · 2020Article
- Article
- Hepatic Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons.Endocrinology · 2017Article
- Peripheral insulin resistance and impaired insulin signaling contribute to abnormal glucose metabolism in preterm baboons.Endocrinology · 2015Article
- Developmental regulation of key gluconeogenic molecules in nonhuman primates.Physiological reports · 2014Article
- Developmental profiles of the intrinsic properties and synaptic function of auditory neurons in preterm and term baboon neonates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Antenatal corticosteroids alter insulin signaling pathways in fetal baboon skeletal muscle.The Journal of endocrinology · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTransient neonatal hyperglycemia (HG) has been reported in up to 80% of extremely preterm human infants. We hypothesize that severe HG is associated with increased morbidity and mortality in preterm baboons.
methodsSixty-six baboons born at 67% of gestation were studied. HG was defined as serum glucose level ≥150 mg/dl during the first week of life. Animals were stratified into two groups: severe HG (≥8 events) and nonsevere HG (<8 events).
resultsHG developed in 65 of the 66 (98%) baboons that were included. A total of 3,386 glucose measurements were obtained. The mean serum glucose level was 159 ± 69 mg/dl for the severe HG group and 130 ± 48 mg/dl for the nonsevere HG group during the first week of life. No differences were found in gender, birth weight, sepsis, patent ductus arteriosus, or oxygenation/ventilation indexes between groups. Severe HG was associated with early death even after controlling for sepsis, postnatal steroid exposure, and catecholamine utilization.
conclusionHG is common in preterm baboons and is not associated with short-term morbidity. Severe HG occurring in the first week of life is associated with early death in preterm baboons.
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