ReviewNature reviews. Cancer2013
Prostate cancer: is it time to expand the research focus to early-life exposures?
Review in Nature reviews. Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Role of vitamin D receptor gene Cdx2 and Apa1 polymorphisms in prostate cancer susceptibility: a meta-analysis.BMC cancer · 2016Pooled it
- Is birthweight associated with total and aggressive/lethal prostate cancer risks? A systematic review and meta-analysis.British journal of cancer · 2016Pooled it
- Prediagnostic Body Mass Index Trajectories in Relation to Prostate Cancer Incidence and Mortality in the PLCO Cancer Screening Trial.Journal of the National Cancer Institute · 2017Trial
- Pre-adult attention-deficit/hyperactive disorder and later adverse health outcomes: the 1987 Finnish birth cohort study.Molecular psychiatry · 2026Article
- A prospective study of birth weight and prostate cancer risk and mortality in the Health Professionals Follow-up Study.British journal of cancer · 2024Article
- Orchestration of miRNA Patterns by Testosterone and Dietary Tomato Carotenoids during Early Prostate Carcinogenesis in TRAMP Mice.The Journal of nutrition · 2023Article
- Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia.International journal of cancer · 2022Article
- Longitudinal trajectories of lifetime body shape and prostate cancer angiogenesis.European journal of epidemiology · 2022Article
- Somatic mutational profiles and germline polygenic risk scores in human cancer.Genome medicine · 2022Article
- Adolescent Plant Product Intake in Relation to Later Prostate Cancer Risk and Mortality in the NIH-AARP Diet and Health Study.The Journal of nutrition · 2021Article
- Prenatal Diethylstilbestrol Exposure and Cancer Risk in Males.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Adolescent animal product intake in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study.British journal of cancer · 2021Article
- Alcohol intake in early adulthood and risk of colorectal cancer: three large prospective cohort studies of men and women in the United States.European journal of epidemiology · 2021Article
- Article
- Early-Life Cardiorespiratory Fitness and Long-term Risk of Prostate Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Adolescent dairy product and calcium intake in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study.Cancer causes & control : CCC · 2020Article
- Body mass index trajectories and prostate cancer risk: Results from the EPICAP study.Cancer medicine · 2020Article
- Racial differences in prostate cancer: does timing of puberty play a role?British journal of cancer · 2020Review
- Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.BMJ (Clinical research ed.) · 2020Article
- Relationship of self-reported body size and shape with risk for prostate cancer: A UK case-control study.PloS one · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Although the contribution of lifestyle and environment (non-genetic factors) to prostate carcinogenesis is indicated by international variation in prostate cancer occurrence and migration studies, no conclusive modifiable risk factors have yet been identified. One possible reason for this may be the dearth of epidemiological research on exposures experienced early in life, when the immature prostate may be more susceptible to carcinogenic exposures. In this Opinion article, we summarize the rationale for studying early-life exposures, describe the small body of early-life research and its associated challenges, and point to solutions for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.