ArticleCaries research2013
Fine-mapping of 5q12.1-13.3 unveils new genetic contributors to caries.
Article in Caries research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Is the caregivers' oral health related to dental caries in children or adolescents? A systematic review.Clinical oral investigations · 2019Pooled it
- Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study.BMC pediatrics · 2023Article
- Genetic Aspects of Dental Erosive Wear and Dental Caries.International journal of dentistry · 2021Review
- Biomarkers for Lifetime Caries-Free Status.Journal of personalized medicine · 2020Article
- Measuring the Microscopic Structures of Human Dental Enamel Can Predict Caries Experience.Journal of personalized medicine · 2020Article
- Are mTOR and Endoplasmic Reticulum Stress Pathway Genes Associated with Oral and Bone Diseases?Caries research · 2019Article
- Redefining the Phenotype of Dental Caries.Caries research · 2018Article
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- Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay.BMC medical genetics · 2014Article
- Caries: review of human genetics research.Caries research · 2014Review
- Genetic mapping of high caries experience on human chromosome 13.BMC medical genetics · 2013Article
- Role of TRAV locus in low caries experience.Human genetics · 2013Article
Corrections and comments
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Authors and funding
25 authors at 9 institutions in 5 countries.
Funding
Abstract
Caries is a multifactorial disease and little is still known about the host genetic factors influencing susceptibility. Our previous genome-wide linkage scan has identified the interval 5q12.1-5q13.3 as linked to low caries susceptibility in Filipino families. Here we fine-mapped this region in order to identify genetic contributors to caries susceptibility. Four hundred and seventy-seven subjects from 72 pedigrees with similar cultural and behavioral habits and limited access to dental care living in the Philippines were studied. DMFT scores and genotype data of 75 single-nucleotide polymorphisms were evaluated in the Filipino families with the Family-Based Association Test. For replication purposes, a total 1,467 independent subjects from five different populations were analyzed in a case-control format. In the Filipino cohort, statistically significant and borderline associations were found between low caries experience and four genes spanning 13 million base pairs (PART1, ZSWIM6, CCNB1, and BTF3). We were able to replicate these results in some of the populations studied. We detected PART1 and BTF3 expression in whole saliva, and the expression of BTF3 was associated with caries experience. Our results suggest BTF3 may have a functional role in protecting against caries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.