ArticleThe oncologist2013
A study to evaluate the cause of bone demineralization in gynecological cancer survivors.
Article in The oncologist, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Prevention and management of radiotherapy-related toxicities in gynecological malignancies. Position paper on behalf of AIRO (Italian Association of Radiotherapy and Clinical Oncology).La Radiologia medica · 2024Guideline
- Research progress of drug-induced osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Pilot study of the effect of surgical menopause on bone mineral density and quality in patients with gynecological malignancies.The journal of obstetrics and gynaecology research · 2025Article
- Cancer treatment-induced bone loss.The Korean journal of internal medicine · 2024Review
- Managing Early Onset Osteoporosis: The Impact of Premature Ovarian Insufficiency on Bone Health.Journal of clinical medicine · 2023Review
- Bone health and evaluation of bone mineral density in patients with premature ovarian insufficiency.Przeglad menopauzalny = Menopause review · 2018Review
- Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2018Article
- Combined aerobic and resistance training improves bone health of female cancer survivors.Bone reports · 2016Article
- Olive oil exhibits osteoprotection in ovariectomized rats without estrogenic effects.Experimental and therapeutic medicine · 2016Article
- Mind the gaps: missed opportunities to promote bone health among cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Prevention and treatment of bone fragility in cancer patient.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal DiseasesReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAn association between treatment for gynecological cancers and risk of osteoporosis has never been formally evaluated. Women treated for these cancers are now living longer than ever before, and prevention of treatment-induced morbidities is important. We aimed to distinguish, in gynecological cancer survivors, whether cancer therapy has additional detrimental effects on bone health above those attributable to hormone withdrawal.
methodsWe performed a retrospective cross-sectional analysis of dual energy x-ray absorptiometry (DEXA) scan results from 105 women; 64 had undergone bilateral salpingo-oophorectomy (BSO) followed by chemotherapy or radiotherapy for gynecological malignancies, and 41 age-matched women had undergone BSO for benign etiologies. All were premenopausal prior to surgery.
resultsThe median age at DEXA scan for the cancer group was 42 years, and 66% had received hormonal replacement therapy (HRT) following their cancer treatment. For the benign group, the median age was 40 years, and 87% had received HRT. Thirty-nine percent of cancer survivors had abnormal DEXA scan results compared to 15% of the control group, with the majority demonstrating osteopenia. The mean lumbar spine and femoral neck bone mineral densities (BMDs) were significantly lower in cancer patients. A history of gynecological cancer treatment was associated with significantly lower BMD in a multivariate logistic regression.
conclusionsWomen treated for gynecological malignancies with surgery and adjuvant chemotherapy have significantly lower BMDs than age-matched women who have undergone oophorectomy for noncancer indications. Prospective evaluation of BMD in gynecological cancer patients is recommended to facilitate interventions that will reduce the risk of subsequent fragility fractures.
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