ArticleBrain, behavior and evolution2013
Variation in human brains may facilitate evolutionary change toward a limited range of phenotypes.
Article in Brain, behavior and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II.Communications biology · 2023Article
- The neuroecology of the water-to-land transition and the evolution of the vertebrate brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Neurodevelopmental scaling is a major driver of brain-behavior differences in temperament across dog breeds.Brain structure & function · 2021Article
- An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution.BMC biology · 2021Article
- Not all cortical expansions are the same: the coevolution of the neocortex and the dorsal thalamus in mammals.Current opinion in neurobiology · 2019Review
- Comparing Adult Hippocampal Neurogenesis Across Species: Translating Time to Predict the Tempo in Humans.Frontiers in neuroscience · 2018Article
- Island Rule, quantitative genetics and brain-body size evolution inProceedings. Biological sciences · 2017Article
- Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Effects of cranial integration on hominid endocranial shape.Journal of anatomy · 2017Article
- When larger brains do not have more neurons: increased numbers of cells are compensated by decreased average cell size across mouse individuals.Frontiers in neuroanatomy · 2015Article
- Modeling local and cross-species neuron number variations in the cerebral cortex as arising from a common mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Genetic constraints predict evolutionary divergence in Dalechampia blossoms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- A framework for the objective assessment of registration accuracy.International journal of biomedical imaging · 2014Article
- Reconsidering the evolution of brain, cognition, and behavior in birds and mammals.Frontiers in psychology · 2013Article
- How brains are built: genetics and evolution.Brain, behavior and evolution · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Individual variation is the foundation for evolutionary change, but little is known about the nature of normal variation between brains. Phylogenetic variation across mammalian brains is characterized by high intercorrelations in brain region volumes, distinct allometric scaling for each brain region and the relative independence of olfactory and limbic structure volumes from the rest of the brain. Previous work examining brain variation in individuals of some domesticated species showed that these three features of phylogenetic variation were mirrored in individual variation. We extend this analysis to the human brain and 10 of its subdivisions (e.g., isocortex and hippocampus) by using magnetic resonance imaging scans of 90 human brains ranging between 16 and 25 years of age. Human brain variation resembles both the individual variation seen in other species and variation observed across mammalian species, i.e., the relative differences in the slopes of each brain region compared to medulla size within humans and between mammals are concordant, and limbic structures scale with relative independence from other brain regions. This nonrandom pattern of variation suggests that developmental programs channel the variation available for selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.