ArticleBMC medical informatics and decision making2013
Risk factors for adverse reactions from contrast agents for computed tomography.
Article in BMC medical informatics and decision making, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
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- CycleGAN-based image-to-image translation for synthetic contrast enhancement in non-contrast cardiac CT: a ViT-CNN hybrid deep learning approach.BMC medical informatics and decision making · 2026Article
- Adverse Reactions to CT Contrast Agents: A 10-Year Study of Clinical and Environmental Risk Factors.Diagnostics (Basel, Switzerland) · 2025Article
- Risk factor analysis of iodinated contrast medium-related hypersensitivity reactions.Insights into imaging · 2025Review
- Efficacy of contrast versus non-contrast CT surveillance among patients surviving two years without recurrence after surgery for stage I lung cancer.Scientific reports · 2025Article
- Feasibility and safety of a percutaneous and non-fluoroscopic procedure for left atrial appendage closure in patients for whom fluoroscopy presents risk: a cohort study.Quantitative imaging in medicine and surgery · 2023Article
- Bridging the gap between bench and clinic: the importance of understanding the mechanism of iodinated contrast media hypersensitivity.The British journal of radiology · 2023Review
- Successful Adrenal Vein Sampling Using Dexamethasone Premedication in Patients With Iodine Contrast Media Allergy.Journal of the Endocrine Society · 2022Article
- Contrast Media Adverse Drug Reactions in Highly Polluted Environment.International journal of environmental research and public health · 2022Article
- Cryoballoon ablation for atrial fibrillation without the use of a contrast medium: a combination of the intracardiac echocardiography and pressure wave monitoring guided approach.Heart and vessels · 2022Article
- Adrenal Vein Sampling in a Patient With Primary Hyperaldosteronism and Severe Contrast Allergy.Journal of the Endocrine Society · 2021Article
- Budget Impact of Microbial Cell-Free DNA Testing Using the KariusApplied health economics and health policy · 2021Article
- Impact on liver position under breath-hold by computed tomography contrast agents in stereotactic body radiotherapy of liver cancer.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2021Article
- Predicting acute adverse contrast mean reactions following cardiac catheterization: a complex undertaking.Journal of thoracic disease · 2019Article
- A Peri-Implant Disease Risk Score for Patients with Dental Implants: Validation and the Influence of the Interval between Maintenance Appointments.Journal of clinical medicine · 2019Article
- Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer.International journal of biomedical imaging · 2019Article
- Immediate Adverse Reactions to Gadolinium-Based MR Contrast Media: A Retrospective Analysis on 10,608 Examinations.BioMed research international · 2016Article
- Imaging Modalities for Assessment of Treatment Response to Nonsurgical Hepatocellular Carcinoma Therapy: Contrast-Enhanced US, CT, and MRI.Liver cancer · 2015Review
- Assessment of immediate and non-immediate hypersensitivity contrast reactions by skin tests and provocation tests: A review.International journal of immunopathology and pharmacologyReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSymptoms of an adverse reaction to contrast agents for computed tomography are diverse ranging, and sometimes serious. The goal of this study is to create a scoring rule to predict adverse reactions to contrast agents used in computed tomography.
methodsThis was a retrospective cohort study of all adult patients undergoing contrast enhanced CT scan for 7 years. The subjects were randomly divided into either a derivation or validation group. Baseline data and clinically relevant factors were collected from the electronic chart. Primary outcome was any acute adverse reactions to contrast media, observed for during 24 hours after administration. All potential candidate predictors were included in a forward stepwise logistic regression model. Prediction scores were assigned based on β coefficient. A receiver operating characteristic (ROC) curve was drawn, and the area under the curve (AUC) and incidence of acute adverse reactions at each point were obtained. The same process was performed in the validation group.
results36,472 patients underwent enhanced CT imaging: 20,000 patients in the derivation group and 16,472 in the validation group. A total of 409 (2.0%, 95% CI:1.9-2.3) and 347 (2.1%, 95% CI:1.9-2.3) acute adverse reactions were seen in the derivation and validation groups. Logistic regression analysis revealed that prior adverse reaction to contrast agents, urticaria, an allergic history to drugs other than contrast agents, contrast agent concentration >70%, age <50 years, and total contrast agent dose >65 g were significant predictors of an acute adverse reaction. AUC was 0.70 (95% CI:0.67-0.73) and 0.67 (95% CI:0.64-0.70) in the derivation and validation groups.
conclusionsWe suggest a prediction model consisting of six predictors for acute adverse reactions to contrast agents used in CT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.