ArticleMolecular biology of the cell2013
akirin is required for diakinesis bivalent structure and synaptonemal complex disassembly at meiotic prophase I.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Cohesin ring gates are specialized for meiotic cell division.Journal of molecular cell biology · 2025Article
- AKIR-1 regulates proteasome subcellular function iniScience · 2023Article
- Newfound features of meiotic chromosome organization that promote efficient congression and segregation inMolecular biology of the cell · 2022Article
- Polycomb group (PcG) proteins prevent the assembly of abnormal synaptonemal complex structures during meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- SYP-5 regulates meiotic thermotolerance in Caenorhabditis elegans.Journal of molecular cell biology · 2021Article
- Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.Journal of cell science · 2020Article
- Akirin proteins in development and disease: critical roles and mechanisms of action.Cellular and molecular life sciences : CMLS · 2020Review
- Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans.PLoS genetics · 2020Article
- Akirin Is Required for Muscle Function and Acts Through the TGF-β Sma/Mab Signaling Pathway inG3 (Bethesda, Md.) · 2020Article
- Article
- Tissue-Specific Split sfGFP System for Streamlined Expression of GFP Tagged Proteins in theG3 (Bethesda, Md.) · 2019Article
- A Novel Role for α-Importins and Akirin in Establishment of Meiotic Sister Chromatid Cohesion inGenetics · 2019Article
- BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis.PLoS genetics · 2018Article
- An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression.Scientific reports · 2018Article
- Evolutionary plasticity in the innate immune function of Akirin.PLoS genetics · 2018Article
- Functional Evolution of Subolesin/Akirin.Frontiers in physiology · 2018Review
- Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis.The Journal of cell biology · 2017Article
- Akirin2 is essential for the formation of the cerebral cortex.Neural development · 2016Article
- Regulating the construction and demolition of the synaptonemal complex.Nature structural & molecular biology · 2016Review
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8 authors.
Funding
Abstract
During meiosis, evolutionarily conserved mechanisms regulate chromosome remodeling, leading to the formation of a tight bivalent structure. This bivalent, a linked pair of homologous chromosomes, is essential for proper chromosome segregation in meiosis. The formation of a tight bivalent involves chromosome condensation and restructuring around the crossover. The synaptonemal complex (SC), which mediates homologous chromosome association before crossover formation, disassembles concurrently with increased condensation during bivalent remodeling. Both chromosome condensation and SC disassembly are likely critical steps in acquiring functional bivalent structure. The mechanisms controlling SC disassembly, however, remain unclear. Here we identify akir-1 as a gene involved in key events of meiotic prophase I in Caenorhabditis elegans. AKIR-1 is a protein conserved among metazoans that lacks any previously known function in meiosis. We show that akir-1 mutants exhibit severe meiotic defects in late prophase I, including improper disassembly of the SC and aberrant chromosome condensation, independently of the condensin complexes. These late-prophase defects then lead to aberrant reconfiguring of the bivalent. The meiotic divisions are delayed in akir-1 mutants and are accompanied by lagging chromosomes. Our analysis therefore provides evidence for an important role of proper SC disassembly in configuring a functional bivalent structure.
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