ArticleProceedings of the National Academy of Sciences of the United States of America2013
Nonspecific uptake and homeostasis drive the oceanic cadmium cycle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 123 citations in OpenAlex.
- Particulate Cadmium Accumulation in the Mesopelagic Ocean.Global biogeochemical cycles · 2025Article
- Stable Isotope Fractionation of Metals and Metalloids in Plants: A Review.Frontiers in plant science · 2022Review
- Changes of Cadmium Storage Forms and Isotope Ratios in Rice During Grain Filling.Frontiers in plant science · 2021Article
- Direct measurement of multi-elements in high matrix samples with a flow injection ICP-MS: application to the extendedJournal of analytical atomic spectrometry · 2018Article
- Rapid Enrichment and Sensitive Detection of Multiple Metal Ions Enabled by Macroporous Graphene Foam.Analytical chemistry · 2017Article
- Diagnosing oceanic nutrient deficiency.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
- Fractionation of Stable Cadmium Isotopes in the Cadmium Tolerant Ricinus communis and Hyperaccumulator Solanum nigrum.Scientific reports · 2016Article
- The oceanic cadmium cycle: biological mistake or utilization?Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Reply to Morel: Cadmium as a micronutrient and macrotoxin in the oceans.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The global marine distributions of Cd and phosphate are closely correlated, which has led to Cd being considered as a marine micronutrient, despite its toxicity to life. The explanation for this nutrient-like behavior is unknown because there is only one identified biochemical function for Cd, an unusual Cd/Zn carbonic anhydrase. Recent developments in Cd isotope mass spectrometry have revealed that Cd uptake by phytoplankton causes isotopic fractionation in the open ocean and in culture. Here we investigate the physiochemical pathways that fractionate Cd isotopes by performing subcellular Cd isotope analysis on genetically modified microorganisms. We find that expression of the Cd/Zn carbonic anhydrase makes no difference to the Cd isotope composition of whole cells. Instead, a large proportion of the Cd is partitioned into cell membranes with a similar direction and magnitude of Cd isotopic fractionation to that seen in surface seawater. This observation is well explained if Cd is mistakenly imported with other divalent metals and subsequently managed by binding within the cell to avoid toxicity. This process may apply to other divalent metals, whereby nonspecific uptake and subsequent homeostasis may contribute to elemental and isotopic distributions in seawater, even for elements commonly considered as micronutrients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.