ArticleEvolutionary bioinformatics online2013
The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway.
Article in Evolutionary bioinformatics online, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Exploring the mechanism of hirudin in the treatment of diabetic kidney disease using network pharmacology combined with molecular docking verification.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Genome-Wide Identification and Analysis ofJournal of fungi (Basel, Switzerland) · 2021Article
- Perturbation of IIS/TOR signaling alters the landscape of sex-differential gene expression in Drosophila.BMC genomics · 2018Article
- Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption.BMC genomics · 2017Article
- Evolutionary patterns of Toll-like receptor signaling pathway genes in the Suidae.BMC evolutionary biology · 2016Article
- Rapid molecular evolution across amniotes of the IIS/TOR network.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Comment on "The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway".Evolutionary bioinformatics online · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insulin/insulin growth factor-1(IGF1)/FOXO (IIF) signal transduction pathway plays a core role in the endocrine system. Although the components of this pathway have been well characterized, the evolutionary pattern remains poorly understood. Here, we perform a comprehensive analysis to study whether the differences of signaling transduction elements exist as well as to determine whether the genes are subject to equivalent evolutionary forces and how natural selection shapes the evolution pattern of proteins in an interacting system. Our results demonstrate that most IIF pathway components are present throughout all animal phyla investigated here, and they are under strong selective constraint. Remarkably, we detect that the components in the middle of the pathway undergo stronger purifying selection, which is different from previous similar reports. We also find that the d(N)/d(S) may be influenced by quite complicated factors including codon bias, protein length among others.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.