SynthesisHuman brain mapping2014
Segregating cognitive functions within hippocampal formation: a quantitative meta-analysis on spatial navigation and episodic memory.
Synthesis in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Specific and disease stage-dependent episodic memory-related brain activation patterns in Alzheimer's disease: a coordinate-based meta-analysis.Brain structure & function · 2015Pooled it
- Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial.Nature medicine · 2026Trial
- Brain Bases for Navigating Acoustic Features.Human brain mapping · 2026Article
- Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine.Molecular psychiatry · 2025Article
- Integration of Euclidean and path distances in hippocampal maps.Scientific reports · 2025Article
- Noninvasive modulation of the hippocampal-entorhinal complex during spatial navigation in humans.Science advances · 2024Article
- Enhanced Cognition and Modulation of Brain Connectivity in Mild Neurocognitive Disorder: The Promise of Transcranial Pulse Stimulation.Biomedicines · 2024Article
- High frequency post-pause word choices and task-dependent speech behavior characterize connected speech in individuals with mild cognitive impairment.medRxiv : the preprint server for health sciences · 2024Article
- Functional connectivity changes of the hippocampal subregions in anti-N-methyl-D-aspartate receptor encephalitis.Brain imaging and behavior · 2024Article
- One step too far: social cerebellum in norm-violating navigation.Social cognitive and affective neuroscience · 2024Article
- Create your own path: social cerebellum in sequence-based self-guided navigation.Social cognitive and affective neuroscience · 2024Article
- Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review.Frontiers in oncology · 2024Review
- Sex and menstrual cycle influence human spatial navigation strategies and performance.Scientific reports · 2023Article
- Mind your step: social cerebellum in interactive navigation.Social cognitive and affective neuroscience · 2023Article
- Magnetic resonance spectroscopy investigation in the right human hippocampus following spinal cord injury.Frontiers in neurology · 2023Article
- The Impact of Right Temporal Lobe Epilepsy On Nonverbal Memory: Meta-regression of Stimulus- and Task-related Moderators.Neuropsychology review · 2022Review
- Abnormal Dynamic Functional Connectivity of the Left Rostral Hippocampus in Predicting Antidepressant Efficacy in Major Depressive Disorder.Psychiatry investigation · 2022Article
- Sex and strategy effects on brain activation during a 3D-navigation task.Communications biology · 2022Article
- Abnormal resting-state functional connectivity of hippocampal subregions in children with primary nocturnal enuresis.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most important cognitive domains where hippocampal formation is crucially involved are navigation and memory. Some evidence suggests that different hippocampal subregions mediate these domains. However, a quantitative meta-analysis on neuroimaging studies of spatial navigation versus memory is lacking. By means of activation likelihood estimation (ALE), we investigate concurrence of brain regions activated during spatial navigation encoding and retrieval as well as during episodic memory encoding and retrieval tasks in humans. During encoding in spatial navigation, activity was located in more posterior regions of the hippocampal formation, whereas episodic memory encoding was located in more anterior regions. Retrieval in spatial navigation was more strongly lateralized to the right compared to episodic memory retrieval. Within studies on spatial navigation retrieval, immediate recall was located more posterior and delayed recall more anterior. Overlap between concurrence of activation in spatial navigation and episodic memory was rather limited in comparison to uniquely involved regions. This argues in favor of two distinct networks, one for spatial navigation the other for episodic memory within the hippocampal formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.