ArticleHuman brain mapping2014
Associations between T1 white matter lesion volume and regional white matter microstructure in aging.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Free water: A marker of age-related modifications of the cingulum white matter and its association with cognitive decline.PloS one · 2020Trial
- Variation in systemic biological health risk is associated with white matter integrity differences in young adult veterans.Brain imaging and behavior · 2026Article
- Use of Multiple Languages Provides Cognitive Reserve Amidst Age-Related White Matter Changes.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Loneliness and biomarkers of brain pathology in people with subjective cognitive decline.Scientific reports · 2025Article
- Connecting the dots: microstructural properties of white matter hyperintensities predict longitudinal cognitive changes in ageing.Frontiers in aging neuroscience · 2025Article
- Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum.Brain communications · 2025Article
- Cerebral Oxygen Metabolic Stress in Children and Adults With Large Vessel Vasculopathy Due to Sickle Cell Disease.Neurology · 2024Article
- Biomarkers of Alzheimer's Disease and Cerebrovascular Disease in Relation to Depressive Symptomatology in Individuals With Subjective Cognitive Decline.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Cholinergic white matter pathways along the Alzheimer's disease continuum.Brain : a journal of neurology · 2023Article
- The canonical pattern of Alzheimer's disease atrophy is linked to white matter hyperintensities in normal controls, differently in normal controls compared to in AD.Neurobiology of aging · 2022Article
- The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Comparing different approaches for operationalizing subjective cognitive decline: impact on syndromic and biomarker profiles.Scientific reports · 2021Article
- Cerebrovascular Disease and Depressive Symptomatology in Individuals With Subjective Cognitive Decline: A Community-Based Study.Frontiers in aging neuroscience · 2021Article
- White Matter Hyperintensity Volume and Location: Associations With WM Microstructure, Brain Iron, and Cerebral Perfusion.Frontiers in aging neuroscience · 2021Article
- Circulating Angiotensin-(1-7) Is Reduced in Alzheimer's Disease Patients and Correlates With White Matter Abnormalities: Results From a Pilot Study.Frontiers in neuroscience · 2021Article
- Heterogeneity of Cerebral White Matter Lesions and Clinical Correlates in Older Adults.Stroke · 2021Article
- Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities.Aging · 2020Article
- Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging.Neurobiology of aging · 2019Article
- Breadth and depth of working memory and executive function compromises in mild cognitive impairment and their relationships to frontal lobe morphometry and functional competence.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Imaging the aged brain: pertinence and methods.Quantitative imaging in medicine and surgery · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
White matter lesions, typically manifesting as regions of signal intensity abnormality (WMSA) on MRI, increase in frequency with age. However, the role of this damage in cognitive decline and disease is still not clear, as lesion volume has only loosely been associated with clinical status. Diffusion tensor imaging (DTI) has been used to examine the quantitative microstructural integrity of white matter, and has applications in the examination of subtle changes to tissue that appear visually normal on conventional imaging. The primary goal of this study was to determine whether major macrostructural white matter damage, (total WMSA volume), is associated with microstructural integrity of normal appearing white matter, and if these macrostructural changes fully account for microstructural changes. Imaging was performed in 126 nondemented individuals, ages 43-85 years, with no history of cerebrovascular disease. Controlling for age, greater WMSA volume was associated with decreased fractional anisotropy (FA) in widespread brain regions. Patterns were similar for FA and radial diffusivity but in contrast, WMSA was associated with axial diffusivity in fewer areas. Age was associated with FA in several regions, and many of these effects remained even when controlling for WMSA volume, suggesting the etiology of WMSAs does not fully account for all age-associated white matter deterioration. These results provide evidence that WMSA volume is associated with the integrity of normal-appearing white matter. In addition, our results suggest that overt lesions may not account for the association of increasing age with decreased white matter tissue integrity.
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