ArticleChembiochem : a European journal of chemical biology2013
Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.
Article in Chembiochem : a European journal of chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Enhanced bafilomycin A1 production in Streptomyces Griseobrunneus via protoplast fusion combined with high-throughput screening.World journal of microbiology & biotechnology · 2025Article
- Genomic Analysis ofAntibiotics (Basel, Switzerland) · 2024Article
- Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds.The Journal of antibiotics · 2024Article
- Elucidation of the Late Steps during Hexacosalactone A Biosynthesis in Streptomyces samsunensis OUCT16-12.Applied and environmental microbiology · 2023Article
- An antimicrobial thiopeptide producing novel actinomycetesFEMS microbes · 2023Article
- Streptomyces clavuligerus: The Omics Era.Journal of industrial microbiology & biotechnology · 2021Article
- Specialized Metabolites from Ribosome Engineered Strains ofMetabolites · 2021Article
- Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine BacteriumMarine drugs · 2021Article
- Genome Sequence of Streptomyces cavourensis 1AS2a, a Rhizobacterium Isolated from the Brazilian Cerrado Biome.Microbiology resource announcements · 2019Article
- Comparative Genomics of Marine Sponge-DerivedFrontiers in microbiology · 2019Article
- Biosynthesis of 2-amino-3-hydroxycyclopent-2-enone moiety of bafilomycin in Kitasatospora cheerisanensis KCTC2395.Journal of microbiology (Seoul, Korea) · 2018Article
- Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms.The Journal of antibiotics · 2017Article
- Complete elucidation of the late steps of bafilomycin biosynthesis inThe Journal of biological chemistry · 2017Article
- The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.Chemical reviews · 2017Review
- Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.Bioorganic & medicinal chemistry · 2016Article
- Increased valinomycin production in mutants of Streptomyces sp. M10 defective in bafilomycin biosynthesis and branched-chain α-keto acid dehydrogenase complex expression.Journal of industrial microbiology & biotechnology · 2015Article
- Analysis of a draft genome sequence of Kitasatospora cheerisanensis KCTC 2395 producing bafilomycin antibiotics.Journal of microbiology (Seoul, Korea) · 2015Article
- Evolution of cyclizing 5-aminolevulinate synthases in the biosynthesis of actinomycete secondary metabolites: outcomes for genetic screening techniques.Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.