ArticleJournal of biomedical materials research. Part B, Applied biomaterials2013
The effect of particle size on the osteointegration of injectable silicate-substituted calcium phosphate bone substitute materials.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Synergistic Effect of Poly(ethylenephosphoric Acid) and Cerium in Bone Substitute Composites on Tissue Response and Bone Remodeling.International journal of molecular sciences · 2025Article
- Decoupling the role of chemistry and microstructure in hMSCs response to an osteoinductive calcium phosphate ceramic.Bioactive materials · 2023Article
- Design and clinical application of injectable hydrogels for musculoskeletal therapy.Bioengineering & translational medicine · 2022Review
- Article
- The Granule Size Mediates the In Vivo Foreign Body Response and the Integration Behavior of Bone Substitutes.Materials (Basel, Switzerland) · 2021Article
- A Bioglass-Based Antibiotic (Vancomycin) Releasing Bone Void Filling Putty to Treat Osteomyelitis and Aid Bone Healing.International journal of molecular sciences · 2021Article
- Utility of Chitra-HASi Granules in Cystic Defects of the Maxillofacial Region: A Pilot Study.Journal of pharmacy & bioallied sciences · 2021Article
- Nanostructured Carbonated Hydroxyapatite Associated to rhBMP-2 Improves Bone Repair in Rat Calvaria.Journal of functional biomaterials · 2020Article
- An Antibiotic-Releasing Bone Void Filling (ABVF) Putty for the Treatment of Osteomyelitis.Materials (Basel, Switzerland) · 2020Article
- Optimising micro-hydroxyapatite reinforced poly(lactide acid) electrospun scaffolds for bone tissue engineering.Journal of materials science. Materials in medicine · 2020Article
- Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration.Acta biomaterialia · 2019Article
- Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass.Biomaterials · 2019Article
- Citrate-based materials fuel human stem cells by metabonegenic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Biological properties of calcium phosphate biomaterials for bone repair: a review.RSC advances · 2018Review
- Comparison of the effects of 45S5 and 1393 bioactive glass microparticles on hMSC behavior.Journal of biomedical materials research. Part A · 2017Article
- D-amino acid inhibits biofilm but not new bone formation in an ovine model.Clinical orthopaedics and related research · 2015Article
- Effects of particle size and porosity on in vivo remodeling of settable allograft bone/polymer composites.Journal of biomedical materials research. Part B, Applied biomaterials · 2015Article
- Small-sized granules of biphasic bone substitutes support fast implant bed vascularization.Biomatter · 2015Article
- A review of the effects of dietary silicon intake on bone homeostasis and regeneration.The journal of nutrition, health & aging · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium phosphate (CaP) particles as a carrier in an injectable bone filler allows less invasive treatment of bony defects. The effect of changing granule size within a poloxamer filler on the osteointegration of silicate-substituted calcium phosphate (SiCaP) bone substitute materials was investigated in an ovine critical-sized femoral condyle defect model. Treatment group (TG) 1 consisted of SiCaP granules sized 1000-2000 μm in diameter (100 vol %). TG2 investigated a granule size of 250-500 μm (75 vol %), TG3 a granule size of 90-125 μm (75 vol %) and TG4 a granule size of 90-125 μm (50 vol %). Following a 4 and 8 week in vivo period, bone area, bone-implant contact, and remaining implant area were quantified within each defect. At 4 weeks, significantly increased bone formation was measured in TG2 (13.32% ± 1.38%) when compared with all other groups (p = 0.021 in all cases). Bone in contact with the bone substitute surface was also significantly higher in TG2. At 8 weeks most new bone was associated within defects containing the smallest granule size investigated (at the lower volume) (TG4) (42.78 ± 3.36%) however this group was also associated with higher amounts of fragmented SiCaP. These smaller particles were phagocytosed by macrophages and did not appear to have a negative influence on healing. In conclusion, SiCaP granules of 250-500 μm in size may be a more suitable scaffold when used as an injectable bone filler and may be a convenient method for treating bony defects.
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