ArticleStroke2013
Common variants within oxidative phosphorylation genes influence risk of ischemic stroke and intracerebral hemorrhage.
Article in Stroke, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The MTHFR C677T Polymorphism and Risk of Intracerebral Hemorrhage in a Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Mitochondrial dysfunction in intracerebral hemorrhage: molecular mechanisms and pathological consequences.Frontiers in cellular neuroscience · 2026Review
- Single-Cell RNA-Seq Revealed the Immune Microenvironment Reprogramming by Dexmedetomidine Treatment in Ischemic Stroke.Molecular neurobiology · 2025Article
- Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway.Journal of translational medicine · 2025Article
- Decoding immune cell dynamics in ischemic stroke: insights from single-cell RNA sequencing analysis.Frontiers in aging neuroscience · 2025Article
- Potential and Challenges of Transcranial Photobiomodulation for the Treatment of Stroke.CNS neuroscience & therapeutics · 2024Review
- The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network.Frontiers in cell and developmental biology · 2024Article
- Examining the Association between Mitochondrial Genome Variation and Coronary Artery Disease.Genes · 2022Article
- Role of Mitophagy in the Pathogenesis of Stroke: From Mechanism to Therapy.Oxidative medicine and cellular longevity · 2022Review
- BYHW Decoction Improves Cognitive Impairments in Rats with Cerebral Microinfarcts via Activation of the PKA/CREB Pathway.Oxidative medicine and cellular longevity · 2022Article
- Identification of Dysregulated Mechanisms and Potential Biomarkers in Ischemic Stroke Onset.International journal of general medicine · 2021Article
- The salvageable brain in acute ischemic stroke. The concept of a reverse mismatch: a mini-review.Metabolic brain disease · 2020Review
- Article
- Association between promoter DNA methylation and gene expression in the pathogenesis of ischemic stroke.Aging · 2019Article
- Identification of key genes and upstream regulators in ischemic stroke.Brain and behavior · 2019Article
- Cerebral Small Vessel Disease (CSVD) - Lessons From the Animal Models.Frontiers in physiology · 2019Review
- Mitophagy, a potential therapeutic target for stroke.Journal of biomedical science · 2018Review
- Disrupting interaction of PSD-95 with nNOS attenuates hemorrhage-induced thalamic pain.Neuropharmacology · 2018Article
- Detection of mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic stroke.PloS one · 2018Article
- Associations of Oxidative Phosphorylation-Related Genes With Deep Intracerebral Hemorrhage in Taiwan.Journal of experimental neuroscience · 2018Article
Corrections and comments
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Authors and funding
34 authors at 12 institutions in 3 countries.
Funding
Abstract
background and purposePrevious studies demonstrated association between mitochondrial DNA variants and ischemic stroke (IS). We investigated whether variants within a larger set of oxidative phosphorylation (OXPHOS) genes encoded by both autosomal and mitochondrial DNA were associated with risk of IS and, based on our results, extended our investigation to intracerebral hemorrhage (ICH).
methodsThis association study used a discovery cohort of 1643 individuals, a validation cohort of 2432 individuals for IS, and an extension cohort of 1476 individuals for ICH. Gene-set enrichment analysis was performed on all structural OXPHOS genes, as well as genes contributing to individual respiratory complexes. Gene-sets passing gene-set enrichment analysis were tested by constructing genetic scores using common variants residing within each gene. Associations between each variant and IS that emerged in the discovery cohort were examined in validation and extension cohorts.
resultsIS was associated with genetic risk scores in OXPHOS as a whole (odds ratio [OR], 1.17; P=0.008) and complex I (OR, 1.06; P=0.050). Among IS subtypes, small vessel stroke showed association with OXPHOS (OR, 1.16; P=0.007), complex I (OR, 1.13; P=0.027), and complex IV (OR, 1.14; P=0.018). To further explore this small vessel association, we extended our analysis to ICH, revealing association between deep hemispheric ICH and complex IV (OR, 1.08; P=0.008).
conclusionsThis pathway analysis demonstrates association between common genetic variants within OXPHOS genes and stroke. The associations for small vessel stroke and deep ICH suggest that genetic variation in OXPHOS influences small vessel pathobiology. Further studies are needed to identify culprit genetic variants and assess their functional consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.