ArticleBehavior genetics2013
Three mutually informative ways to understand the genetic relationships among behavioral disinhibition, alcohol use, drug use, nicotine use/dependence, and their co-occurrence: twin biometry, GCTA, and genome-wide scoring.
Article in Behavior genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.Biological psychiatry · 2019Pooled it
- Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression.Translational psychiatry · 2019Trial
- Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment.The American journal of psychiatry · 2026Article
- Parental Alcohol Use Predicts Neural Emotion Reactivity and Substance Use Intentions in Early Adolescence.The Journal of early adolescence · 2025Article
- Generalized genetic liability to substance use disorders.The Journal of clinical investigation · 2024Review
- Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples.Development and psychopathology · 2024Article
- Polygenic Effects on Individual Rule Breaking, Peer Rule Breaking, and Alcohol Sips Across Early Adolescence in the ABCD Study.Research on child and adolescent psychopathology · 2023Article
- The relationship between alcohol- and sleep-related traits: Results from polygenic risk score and Mendelian randomization analyses.Drug and alcohol dependence · 2023Article
- Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach.Scientific reports · 2023Article
- Polygenic risk score for problematic alcohol use predicts heavy drinking and alcohol use disorder symptoms in young adulthood after accounting for adolescent alcohol use and parental alcohol use disorder.Drug and alcohol dependence · 2023Article
- Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin study.Psychological medicine · 2023Article
- Heritable Risk and Protective Genetic Components of Glaucoma Medication Non-Adherence.International journal of molecular sciences · 2023Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- Longitudinal effects and environmental moderation ofDevelopment and psychopathology · 2022Article
- Detection of Parent-of-Origin Effects for the Variants Associated With Behavioral Disinhibition in the MCTFR Data.Frontiers in genetics · 2022Article
- The changing relationship between health risk behaviors and depression among birth cohorts of Canadians 65+, 1994-2014.Frontiers in psychiatry · 2022Article
- Polygenic Risk for Aggression Predicts Adult Substance Use Disorder Diagnoses via Substance Use Offending in Emerging Adulthood and is Moderated by a Family-Centered Intervention.Behavior genetics · 2021Article
- Shared Environmental Influences on Electronic Cigarette Use Among Adolescent and Young Adult Females.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Article
- A statistical measure for the skewness of X chromosome inactivation for quantitative traits and its application to the MCTFR data.BMC genomic data · 2021Article
- Sensation seeking, impulsivity, and aggression moderate sex effects on adolescent laboratory binging.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021Article
7 more citing papers are in PubMed but not listed here.
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Abstract
Behavioral disinhibition is a trait hypothesized to represent a general vulnerability to the development of substance use disorders. We used a large community-representative sample (N = 7,188) to investigate the genetic and environmental relationships among measures of behavioral disinhibition, Nicotine Use/Dependence, Alcohol Consumption, Alcohol Dependence, and Drug Use. First, using a subsample of twins (N = 2,877), we used standard twin models to estimate the additive genetic, shared environmental, and non-shared environmental contributions to these five traits. Heritabilities ranged from .42 to .58 and shared environmental effects ranged from .12 to .24. Phenotypic correlations among the five traits were largely attributable to shared genetic effects. Second, we used Genome-wide Complex Trait Analysis (GCTA) to estimate as a random effect the aggregate genetic effect attributable to 515,384 common SNPs. The aggregated SNPs explained 10-30 % of the variance in the traits. Third, a genome-wide scoring approach summed the actual SNPs, creating a SNP-based genetic risk score for each individual. After tenfold internal cross-validation, the SNP sumscore correlated with the traits at .03 to .07 (p < .05), indicating small but detectable effects. SNP sumscores generated on one trait correlated at approximately the same magnitude with other traits, indicating detectable pleiotropic effects among these traits. Behavioral disinhibition thus shares genetic etiology with measures of substance use, and this relationship is detectable at the level of measured genomic variation.
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