ReviewIrish journal of medical science2013
Targeting tumour necrosis factor-α in hypoxia and synaptic signalling.
Review in Irish journal of medical science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Changes in Neuroimmunological Synapses During Cerebral Ischemia.Translational stroke research · 2025Review
- Potential Key Proteins, Molecular Networks, and Pathways in Perinatal Hypoxia.Neurotoxicity research · 2023Article
- Blocking Formation of Neurotoxic Reactive Astrocytes is Beneficial Following Stroke.bioRxiv : the preprint server for biology · 2023Article
- Blocking of microglia-astrocyte proinflammatory signaling is beneficial following stroke.Frontiers in molecular neuroscience · 2023Article
- New Mechanisms and Targets of Subarachnoid Hemorrhage: A Focus on Mitochondria.Current neuropharmacology · 2022Review
- HIV infection of astrocytes compromises inter-organelle interactions and inositol phosphate metabolism: A potential mechanism of bystander damage and viral reservoir survival.Progress in neurobiology · 2021Article
- Cardiac Arrest Induced by Asphyxia Versus Ventricular Fibrillation Elicits Comparable Early Changes in Cytokine Levels in the Rat Brain, Heart, and Serum.Journal of the American Heart Association · 2021Article
- Tumour Necrosis Factor in Neuroplasticity, Neurogenesis and Alcohol Use Disorder.Brain plasticity (Amsterdam, Netherlands) · 2020Review
- Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System.Oxidative medicine and cellular longevity · 2020Review
- Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression.Frontiers in psychiatry · 2019Review
- Tumor necrosis factor alpha in sleep regulation.Sleep medicine reviews · 2018Review
- Ethyl Pyruvate Attenuates Early Brain Injury Following Subarachnoid Hemorrhage in the Endovascular Perforation Rabbit Model Possibly Via Anti-inflammation and Inhibition of JNK Signaling Pathway.Neurochemical research · 2017Article
- Therapeutic Potentials of Synapses after Traumatic Brain Injury: A Comprehensive Review.Neural plasticity · 2017Review
- The Effects of Hypoxia and Inflammation on Synaptic Signaling in the CNS.Brain sciences · 2016Review
- Article
- Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?Cellular and molecular life sciences : CMLS · 2015Review
- Tumor necrosis factor-α potentiates long-term potentiation in the rat dentate gyrus after acute hypoxia.Journal of neuroscience research · 2015Article
- Etanercept alleviates early brain injury following experimental subarachnoid hemorrhage and the possible role of tumor necrosis factor-α and c-Jun N-terminal kinase pathway.Neurochemical research · 2015Article
- Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats.BioMed research international · 2015Article
- δ-Opioid receptors and inflammatory cytokines in hypoxia: differential regulation between glial and neuron-like cells.Translational stroke research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumour necrosis factor (TNF)-α is a pro-inflammatory cytokine, which is synthesised and released in the brain by astrocytes, microglia and neurons in response to numerous internal and external stimuli. It is involved in many physiological and pathophysiological processes such as gene transcription, cell proliferation, apoptosis, synaptic signalling and neuroprotection. The complex actions of TNF-α in the brain are under intense investigation. TNF-α has the ability to induce selective necrosis of some cells whilst sparing others and this has led researchers to discover multiple activated signalling cascades. In many human diseases including acute stroke and inflammation and those involving hypoxia, levels of TNF-α are increased throughout different brain regions. TNF-α signalling may also have several positive and negative effects on neuronal function including glutamatergic synaptic transmission and plasticity. Exogenous TNF-α may also exacerbate the neuronal response to hypoxia. This review will summarise the actions of TNF-α in the central nervous system on synaptic signalling and its effects during hypoxia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.