ArticleDigestive diseases and sciences2013
Prior endoscopy in patients with newly diagnosed celiac disease: a missed opportunity?
Article in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Current Evidence on Computer-Aided Diagnosis of Celiac Disease: Systematic Review.Frontiers in pharmacology · 2020Pooled it
- Diagnostic clues in patients with clinical malabsorption and pathological small intestinal villous atrophy: Immune-mediated type and beyond.World journal of gastroenterology · 2026Review
- Association of celiac disease with eosinophilic esophagitis: Nationwide register-based cohort study with sibling analyses.The journal of allergy and clinical immunology. Global · 2024Article
- The Usefulness of Intraepithelial Lymphocyte Immunophenotype Testing for the Diagnosis of Coeliac Disease in Clinical Practice.Nutrients · 2024Article
- Computer-Based Diagnosis of Celiac Disease by Quantitative Processing of Duodenal Endoscopy Images.Diagnostics (Basel, Switzerland) · 2023Article
- The global burden of coeliac disease: opportunities and challenges.Nature reviews. Gastroenterology & hepatology · 2022Review
- Do gastroenterologists have medical inertia towards coeliac disease? A UK multicentre secondary care study.BMJ open gastroenterology · 2021Article
- Review
- Rates of Duodenal Biopsy During Upper Endoscopy Differ Widely Between Providers: Implications for Diagnosis of Celiac Disease.Journal of clinical gastroenterology · 2019Article
- Factors associated with number of duodenal samples obtained in suspected celiac disease.Endoscopy international open · 2017Article
- Duodenal Bulb Biopsies Remain Relevant in the Diagnosis of Adult Celiac Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2016Article
- Bulb Biopsy in Adult Celiac Disease: Pros Outweigh the Cons?The American journal of gastroenterology · 2016Article
- Endoscopic evaluation of celiac disease severity and its correlation with histopathological aspects of the duodenal mucosa.Endoscopy international open · 2016Article
- Celiac disease and non-celiac gluten sensitivity.BMJ (Clinical research ed.) · 2015Review
- Cost Effectiveness of Routine Duodenal Biopsy Analysis for Celiac Disease During Endoscopy for Gastroesophageal Reflux.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
- The Role of Endoscopy in the Diagnosis of Celiac Disease.Gastroenterology & hepatology · 2014Article
- Limited utilization of serologic testing in patients undergoing duodenal biopsy for celiac disease.BMC gastroenterology · 2013Article
- Celiac disease: clinch the diagnosis when it is just around the corner.Digestive diseases and sciences · 2013Article
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7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCeliac disease (CD) is under-diagnosed in the United States, and factors related to the performance of endoscopy may be contributory.
aimTo identify newly diagnosed patients with CD who had undergone a prior esophagogastroduodenoscopy (EGD) and examine factors contributing to the missed diagnosis.
methodsWe identified all patients age ≥ 18 years whose diagnosis of CD was made by endoscopy with biopsy at our institution (n = 316), and searched the medical record for a prior EGD. We compared those patients with a prior EGD to those with without a prior EGD with regard to age at diagnosis and gender, and enumerated the indications for EGD.
resultsOf the 316 patients diagnosed by EGD with biopsy at our center, 17 (5 %) had previously undergone EGD. During the prior non-diagnostic EGD, a duodenal biopsy was not performed in 59 % of the patients, and ≥ 4 specimens (the recommended number) were submitted in only 29 % of the patients. On the diagnostic EGD, ≥ 4 specimens were submitted in 94 %. The mean age of diagnosis of those with missed/incident CD was 53.1 years, slightly older than those diagnosed with CD on their first EGD (46.8 years, p = 0.11). Both groups were predominantly female (missed/incident CD: 65 vs. 66 %, p = 0.94).
conclusionsAmong 17 CD patients who had previously undergone a non-diagnostic EGD, non-performance of duodenal biopsy during the prior EGD was the dominant feature. Routine performance of duodenal biopsy during EGD for the indications of dyspepsia and reflux may improve CD diagnosis rates.
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