ArticleNeuro-oncology2013
Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology.
Article in Neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Clinicopathological and Prognostic Roles of STAT3 and Its Phosphorylation in Glioma.Disease markers · 2020Pooled it
- An Updated and Comprehensive Meta-Analysis of Association Between Seven Hot Loci Polymorphisms from Eight GWAS and Glioma Risk.Molecular neurobiology · 2016Pooled it
- Differential expression of the circadian clock network correlates with tumour progression in gliomas.BMC medical genomics · 2023Article
- Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis.Journal of neuro-oncology · 2019Article
- Somatic Mosaicism of IDH1 R132H Predisposes to Anaplastic Astrocytoma: A Case of Two Siblings.Frontiers in oncology · 2019Article
- Genome-Wide Association Studies in Glioma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Review
- Cumulative Evidence for Relationships Between 8q24 Variants and Prostate Cancer.Frontiers in physiology · 2018Article
- Towards an advanced cell-basedAIMS genetics · 2018Review
- Treatment of glioblastoma in adults.Therapeutic advances in neurological disorders · 2018Review
- Understanding inherited genetic risk of adult glioma - a review.Neuro-oncology practice · 2016Article
- Telomere maintenance and the etiology of adult glioma.Neuro-oncology · 2015Review
- Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time.International journal of cancer · 2015Article
- Molecular Markers in Low-Grade Glioma-Toward Tumor Reclassification.Seminars in radiation oncology · 2015Review
- Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.The New England journal of medicine · 2015Article
- CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.Journal of neuropathology and experimental neurology · 2015Article
- Survival and low-grade glioma: the emergence of genetic information.Neurosurgical focus · 2015Article
- The epidemiology of glioma in adults: a "state of the science" review.Neuro-oncology · 2014Review
- Genetics in glioma: lessons learned from genome-wide association studies.Current opinion in neurology · 2013Review
- Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.Neuro-oncology · 2013Article
- What do we know about IDH1/2 mutations so far, and how do we use it?Acta neuropathologica · 2013Review
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32 authors at 6 institutions in 1 country.
Funding
Abstract
introductionRecent discoveries of inherited glioma risk loci and acquired IDH mutations are providing new insights into glioma etiology. IDH mutations are common in lower grade gliomas and secondary glioblastomas and uncommon in primary glioblastomas. Because the inherited variant in 11q23 has been associated with risk of lower grade glioma and not with glioblastomas, we hypothesized that this variant increases susceptibility to IDH-mutated gliomas, but not to IDH-wild-type gliomas.
methodsWe tested this hypothesis in patients with glioma and controls from the San Francisco Adult Glioma Study, the Mayo Clinic, and Illumina controls (1102 total patients, 5299 total controls). Case-control additive associations of 11q23 risk alleles (rs498872, T allele) were calculated using logistic regression, stratified by tumor IDH status (mutated or wild-type) and by histology and grade. We also adjusted for the recently discovered 8q24 glioma risk locus rs55705857 G allele.
resultsThe 11q23 glioma risk locus was associated with increased risk of IDH-mutated gliomas of all histologies and grades (odds ratio [OR] = 1.50; 95% confidence interval [CI] = 1.29-1.74; P = 1.3X10(-7)) but not with IDH-wild-type gliomas of any histology or grade (OR = 0.91; 95% CI = 0.81-1.03; P = 0.14). The associations were independent of the rs55705857 G allele.
conclusionA variant at the 11q23 locus increases risk for IDH-mutated but not IDH-wild-type gliomas, regardless of grade or histology.
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