Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2013
Ultrasonographic markers of vascular risk in patients with asymptomatic carotid stenosis.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Plaque echolucency and stroke risk in asymptomatic carotid stenosis: a systematic review and meta-analysis.Stroke · 2015Pooled it
- Asymptomatic Extracranial Artery Stenosis and the Risk of Cardiovascular and Cerebrovascular Diseases.Scientific reports · 2016Trial
- Relationship between maximum carotid plaque area and prognosis of patients with acute ischaemic stroke.Irish journal of medical science · 2024Article
- Carotid plaque ulceration: unquantified predictor of stroke.BJS open · 2023Article
- Stroke territory and atherosclerosis in ischemic stroke patients with a history of migraine with aura.Frontiers in neurology · 2023Article
- Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness.International journal of environmental research and public health · 2022Article
- Dynamic Changes of Carotid Atherosclerosis and Their Relation with Stroke Recurrence in Patients with Stroke or Transient Ischemic Attack.Current neurovascular research · 2022Article
- Impact of carotid stenosis on cerebral hemodynamic failure and cognitive impairment progression: a narrative review.Annals of translational medicine · 2021Review
- Urinary Proteomics Identifying Novel Biomarkers for the Diagnosis and Phenotyping of Carotid Artery Stenosis.Frontiers in molecular biosciences · 2021Article
- Correlation of coronary artery calcium score and carotid artery intima-media thickness with severity of coronary artery disease.Journal of cardiovascular and thoracic research · 2020Article
- How to identify which patients with asymptomatic carotid stenosis could benefit from endarterectomy or stenting.Stroke and vascular neurology · 2018Review
- Functional Assessment of Intermediate Vascular Disease.BioMed research international · 2018Review
- Carotid Artery Stenosis: Medical Therapy, Surgery, and Stenting.Current neurology and neuroscience reports · 2017Review
- Aortic velocity propagation: A novel echocardiographic method in predicting atherosclerotic coronary artery disease burden.Journal of the Saudi Heart Association · 2017Article
- Optimizing the Definitions of Stroke, Transient Ischemic Attack, and Infarction for Research and Application in Clinical Practice.Frontiers in neurology · 2017Article
- Carotid intima media thickness and blood biomarkers of atherosclerosis in patients after stroke or myocardial infarction.Croatian medical journal · 2016Article
- Duplex-assisted carotid artery stenting without administration of contrast medium for patients with chronic kidney disease or allergic reaction.Neuroradiology · 2016Article
- Medical and Revascularization Therapies for Asymptomatic Carotid Stenosis.Current atherosclerosis reports · 2015Review
- Sex-associated differences in the modulation of vascular risk in patients with asymptomatic carotid stenosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Evaluation and management of plaque protrusion or thrombus following carotid artery stenting.Neurologia medico-chirurgica · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Six-hundred twenty-one subjects with unilateral asymptomatic severe internal carotid artery (ICA) stenosis were prospectively evaluated with a median follow-up of 27 months (min=6, max=68). Vascular risk profile, plaque characteristic, stenosis progression, and common carotid artery intima-media thickness (IMT) were investigated in all patients. Outcome measures were occurrence of ischemic stroke ipsilateral to ICA stenosis and vascular death, while myocardial infarction, contralateral strokes, and transient ischemic attack were considered as competing events. A total of 99 subjects (15.9%) suffered from a vascular event. Among them, 39 were strokes ipsilateral to the stenosis (6.3%). Degree of stenosis, stenosis progression, and common carotid artery IMT resulted as independent predictive factors of ipsilateral stroke. Considering a stenosis of 60% to 70% as reference, a degree between 71% and 90% increased the risk by 2.45, while a degree between 91% and 99% increased the risk by 3.26. The progression of stenosis was a strong risk factor (hazard ratio=4.32). Finally, the role of carotid IMT was confirmed as crucial additional measure, with an increased risk by 25% for each 0.1 mm IMT increase. Our data suggest that IMT, stenosis progression and severity should be considered as risk factors for cerebrovascular events in asymptomatic subjects with severe ICA stenosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.