Evidence map›Paper›PMID 23361260›Full record

Trial reportSurgical endoscopy2013

Comparison of results from a randomized trial 1 year after laparoscopic Nissen and Toupet fundoplications.

Oliver O Koch, Adolf Kaindlstorfer, Stavros A Antoniou, Ruzica Rosalia Luketina, Klaus Emmanuel, Rudolph Pointner

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01321294 (Laparoscopic Nissen Versus Toupet Fundoplication), which is not on this map. Cited by 31 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01321294 nacompletednot on this map

Laparoscopic Nissen Versus Toupet Fundoplication: Objective and Subjective Results of a Prospective Randomized Trial

TypeinterventionalSponsorGeneral Public Hospital Zell am SeeConditionsGastroesophageal Reflux Disease, Laparoscopic Antireflux SurgeryArmslaparoscopic anti-reflux surgery
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Guideline
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  15. Devices for esophageal function testing.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2022
    Article
  16. Impedance Planimetry (Endoflip™) Shows That Length of Narrowing After Fundoplication Does Not Impact Dysphagia.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022
    Article
  17. pH Impedance Parameters Associated with Improvement in GERD Health-Related Quality of Life Following Anti-reflux Surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Article
  18. ENDOSCOPIC EVALUATION OF POST-FUNDOPLICATION ANATOMY AND CORRELATION WITH SYMPTOMATOLOGY.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Oliver O KochDepartment of General Surgery, General Hospital Zell am See, 5700 Zell am See, Austria. oliver.owen.koch@gmail.com
Adolf Kaindlstorfer
Stavros A Antoniou
Ruzica Rosalia Luketina
Klaus Emmanuel
Rudolph Pointner

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe fundoplication of choice for the surgical treatment of gastroesophageal reflux disease (GERD) still is debated. Multichannel intraluminal impedance monitoring (MII) has not been used to compare objective data, and comparative subjective data on laparoscopic Nissen and Toupet fundoplications are scarce.

methodsThis study randomly allocated 125 patients with documented chronic GERD to either laparoscopic floppy Nissen fundoplication (LNF; n = 62) or laparoscopic Toupet fundoplication (LTF; n = 63). The Gastrointestinal Quality of Life Index (GIQLI), symptom grading, esophageal manometry, and MII data were documented preoperatively and 1 year after surgery. The pre- and postprocedure data were compared. Statistical significance was set at a p value lower than 0.01 (NCT01321294).

resultsBoth procedures resulted in significantly improved GIQLI and GERD symptoms. Preoperative dysphagia improved in both groups, but the improvement reached significance only in the LTF group. The ability to belch was shown to be significantly more decreased after LNF than after LTF. Gas-bloat and "atypical" extraesophageal symptoms also were decreased after surgery (p < 0.01). However, bowel symptoms were virtually unchanged in both groups. Both procedures resulted in significantly improved lower esophageal sphincter pressures. The improvement was greater in the LNF group than in the LTF group (p < 0.01). The DeMeester score and the numbers of total, acid, proximal, upright, and recumbent reflux episodes decreased in both groups after surgery (p < 0.01). No significant difference between the procedures in terms of MII data was found. Six patients (4.8 %) had to undergo reoperation because of intrathoracic slipping of the wrap. All the patients had undergone LNF.

conclusionsBoth procedures proved to be equally effective in improving quality of life and GERD symptoms. However, the reoperation and dysphagia rates were lower and the ability to belch was higher after LTF than after LNF.

Indexed as

LaparoscopyAdultAgedAged, 80 and overDeglutition DisordersEructationEsophageal pH MonitoringEsophageal Sphincter, LowerFemaleFundoplicationGastroesophageal RefluxHumansMaleManometryMiddle AgedPressure

Identifiers

PMID23361260

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.