ArticleSleep & breathing = Schlaf & Atmung2013
Mortality in middle-aged men with obstructive sleep apnea in Finland.
Article in Sleep & breathing = Schlaf & Atmung, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sudden death in individuals with obstructive sleep apnoea: a systematic review and meta-analysis.BMJ open respiratory research · 2021Pooled it
- Meta-analysis of all-cause and cardiovascular mortality in obstructive sleep apnea with or without continuous positive airway pressure treatment.Sleep & breathing = Schlaf & Atmung · 2017Pooled it
- Obstructive sleep apnoea and risks of all-cause mortality: preliminary evidence from prospective cohort studies.Sleep & breathing = Schlaf & Atmung · 2016Pooled it
- Intra-night variation in apnea-hypopnea index affects diagnostics and prognostics of obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2020Article
- Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea.Scientific reports · 2019Article
- Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea.Scientific reports · 2019Article
- Bayesian Network Model to Evaluate the Effectiveness of Continuous Positive Airway Pressure Treatment of Sleep Apnea.Healthcare informatics research · 2018Article
- Severity of individual obstruction events is gender dependent in sleep apnea.Sleep & breathing = Schlaf & Atmung · 2017Article
- Prevalence of Obstructive Sleep Apnoea Among Patients Admitted for Bariatric Surgery. A Prospective Multicentre Trial.Obesity surgery · 2016Article
- Length of Individual Apnea Events Is Increased by Supine Position and Modulated by Severity of Obstructive Sleep Apnea.Sleep disorders · 2016Article
- IGF-1: a potential biomarker for efficacy of sleep improvement with automatic airway pressure therapy for obstructive sleep apnea?Sleep & breathing = Schlaf & Atmung · 2015Observational
- Morbidity and mortality risk ratios are elevated in severe supine dominant OSA: a long-term follow-up study.Sleep & breathing = Schlaf & Atmung · 2015Article
- Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients.Nature and science of sleep · 2015Article
- Adjustment of apnea-hypopnea index with severity of obstruction events enhances detection of sleep apnea patients with the highest risk of severe health consequences.Sleep & breathing = Schlaf & Atmung · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionObstructive sleep apnea (OSA) has been associated with an elevated rate of cardiovascular mortality. However, this issue has not been investigated in patients with elevated proneness to cardiovascular diseases. Our hypothesis was that OSA would have an especially adverse effect on the risk of cardiovascular mortality in Finnish individuals exhibiting elevated proneness for coronary heart diseases.
methodsAmbulatory polygraphic recordings from 405 men having suspected OSA were retrospectively analyzed. The patients were categorized regarding sleep disordered breathing into a normal group (apnea hypopnea index (AHI) < 5, n = 104), mild OSA group (5 ≤ AHI < 15, n = 100), and moderate to severe OSA group (AHI ≥ 15, n = 201). In addition, basic anthropometric and health data were collected. In patients who died during the follow-up period (at least 12 years and 10 months), the primary and secondary causes of death were recorded.
resultsAfter adjustment for age, BMI, and smoking, the patients with moderate to severe OSA suffered significantly (p < 0.05) higher mortality (hazard ratio 3.13) than their counterparts with normal recordings. The overall mortality in the moderate to severe OSA group was 26.4 %, while in the normal group it was 9.7 %. Hazard ratio for cardiovascular mortality was 4.04 in the moderate to severe OSA and 1.87 in the mild OSA group.
conclusionsOSA seems to have an especially adverse effect on the cardiovascular mortality of patients with an elevated genetic susceptibility to coronary heart diseases. When considering that all our patients had possibility of continuous positive airway pressure treatment and our reference group consisted of patients suffering from daytime somnolence, the hazard ratio of 4.04 for cardiovascular mortality in patients with moderate to severe disease is disturbingly high.
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