ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Elevating endogenous GABA levels with GAT-1 blockade modulates evoked but not induced responses in human visual cortex.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- No effects of transcranial direct current stimulation on visual evoked potential and peak gamma frequency.Cognitive processing · 2022Trial
- GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Trial
- Resting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Codevelopment of gut microbial metabolism and visual neural circuitry over human infancy.mBio · 2025Article
- Reduced evoked cortical beta and gamma activity and neuronal synchronization in succinic semialdehyde dehydrogenase deficiency, a disorder of γ-aminobutyric acid metabolism.Brain communications · 2023Article
- The interaction between endogenous GABA, functional connectivity, and behavioral flexibility is critically altered with advanced age.Communications biology · 2022Article
- Tiagabine induced modulation of oscillatory connectivity and activity match PET-derived, canonical GABA-A receptor distributions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Article
- A multimodal magnetoencephalography 7 T fMRI and 7 T proton MR spectroscopy study in first episode psychosis.NPJ schizophrenia · 2020Article
- The circadian clock geneFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Neurotransmitter deficits from frontotemporal lobar degeneration.Brain : a journal of neurology · 2018Review
- On the Physiological Modulation and Potential Mechanisms Underlying Parieto-Occipital Alpha Oscillations.Frontiers in computational neuroscience · 2018Review
- A mean field model for movement induced changes in the beta rhythm.Journal of computational neuroscience · 2017Article
- Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study.Scientific reports · 2017Article
- Significant reductions in human visual gamma frequency by the gaba reuptake inhibitor tiagabine revealed by robust peak frequency estimation.Human brain mapping · 2016Article
- Gamma oscillations in V1 are correlated with GABA(A) receptor density: A multi-modal MEG and Flumazenil-PET study.Scientific reports · 2015Article
- Short-term monocular deprivation alters early components of visual evoked potentials.The Journal of physiology · 2015Article
- Frequency of gamma oscillations in humans is modulated by velocity of visual motion.Journal of neurophysiology · 2015Article
- Individual peak gamma frequency predicts switch rate in perceptual rivalry.Human brain mapping · 2015Article
- Acute effects of alcohol on stimulus-induced gamma oscillations in human primary visual and motor cortices.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Broadband cortical desynchronization underlies the human psychedelic state.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
The electroencephalographic/magnetoencephalographic (EEG/MEG) signal is generated primarily by the summation of the postsynaptic currents of cortical principal cells. At a microcircuit level, these glutamatergic principal cells are reciprocally connected to GABAergic interneurons. Here we investigated the relative sensitivity of visual evoked and induced responses to altered levels of endogenous GABAergic inhibition. To do this, we pharmacologically manipulated the GABA system using tiagabine, which blocks the synaptic GABA transporter 1, and so increases endogenous GABA levels. In a single-blinded and placebo-controlled crossover study of 15 healthy participants, we administered either 15 mg of tiagabine or a placebo. We recorded whole-head MEG, while participants viewed a visual grating stimulus, before, 1, 3 and 5 h post tiagabine ingestion. Using beamformer source localization, we reconstructed responses from early visual cortices. Our results showed no change in either stimulus-induced gamma-band amplitude increases or stimulus-induced alpha amplitude decreases. However, the same data showed a 45% reduction in the evoked response component at ∼80 ms. These data demonstrate that, in early visual cortex the evoked response shows a greater sensitivity compared with induced oscillations to pharmacologically increased endogenous GABA levels. We suggest that previous studies correlating GABA concentrations as measured by magnetic resonance spectroscopy to gamma oscillation frequency may reflect underlying variations such as interneuron/inhibitory synapse density rather than functional synaptic GABA concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.