Evidence map›Paper›PMID 23360977›Full record

GuidelineAlzheimer's & dementia : the journal of the Alzheimer's Association2013

Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association.

Keith A Johnson, Satoshi Minoshima, Nicolaas I Bohnen, Kevin J Donohoe, Norman L Foster, Peter Herscovitch, Jason H Karlawish, Christopher C Rowe, Maria C Carrillo, Dean M Hartley and 6 more

Open access · bronzeAbstract readPractice Guideline
In one paragraph

Guideline in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 274 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 7 pooled it
29.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

274 citing papers in PubMed, 7 syntheses or guidelines pooled it, 585 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  4. Pooled it
  5. Pooled it
  6. Pooled it
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  8. Trial
  9. Trial
  10. Quantitative agreement between AMYclz and CortexID forJapanese journal of radiology · 2026
    Article
  11. Review
  12. Review
  13. Article
  14. Is there a link between multiple sclerosis and Alzheimer disease? A critical note.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  15. Radiomics-enhancedEuropean radiology experimental · 2026
    Article
  16. Sequential scans ofJapanese journal of radiology · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

214 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 2 countries.

Keith A JohnsonDepartments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Satoshi Minoshima
Nicolaas I Bohnen
Kevin J Donohoe
Norman L Foster
Peter Herscovitch
Jason H Karlawish
Christopher C Rowe
Maria C Carrillo
Dean M Hartley
Saima Hedrick
Virginia Pappas
William H Thies
Alzheimer's Association
Society of Nuclear Medicine and Molecular Imaging
Amyloid Imaging Taskforce
Alzheimer's Association · USSociety of Nuclear Medicine and Molecular Imaging · USAustin Health · AUBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · USNational Institutes of Health Clinical Center · USUniversity of Pennsylvania · USUniversity of Utah · USUniversity of Washington · USVA Ann Arbor Healthcare System · US

Funding

Vascular factors, physical activity, and inflammation as modulators of neurodegenerative and cognitive trajectories (Project 2)P01AG036694 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI REISA A. SPERLING · 2010 to 2026
$50.2M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
Evolution of memory-related fMRI activation over the course of MCI and ADR01AG027435 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI JOHNSON, KEITH A., SPERLING, REISA A. · 2006 to 2016
$8.6M
Characterizing the Evolution of Amyloid Deposition in Normal ElderlyR01AG037497 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSON, KEITH A. · 2010 to 2014
$3.2M
NIA NIH HHS P01 AG036694NIA NIH HHS P50 AG005134NIA NIH HHS R01 AG027435NIA NIH HHS R01 AG037497
6 · The paper itself

Abstract

Positron emission tomography (PET) of brain amyloid b is a technology that is becoming more available, but its clinical utility in medical practice requires careful definition. To provide guidance to dementia care practitioners, patients, and caregivers, the Alzheimer's Association and the Society of Nuclear Medicine and Molecular Imaging convened the Amyloid Imaging Taskforce (AIT). The AIT considered a broad range of specific clinical scenarios in which amyloid PET could potentially be used appropriately. Peer-reviewed, published literature was searched to ascertain available evidence relevant to these scenarios, and the AIT developed a consensus of expert opinion. Although empirical evidence of impact on clinical outcomes is not yet available, a set of specific appropriate use criteria (AUC) were agreed on that define the types of patients and clinical circumstances in which amyloid PET could be used. Both appropriate and inappropriate uses were considered and formulated,and are reported and discussed here. Because both dementia care and amyloid PET technology are in active development, these AUC will require periodic reassessment. Future research directions are also outlined, including diagnostic utility and patient-centered outcomes.

Indexed as

Amyloid beta-PeptidesAlzheimer DiseaseBrainHumansNuclear MedicinePositron-Emission TomographyAmyloid beta-Peptides

Identifiers

PMID23360977
PMCPMC3733252
OpenAlexW2103346709

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.