Evidence map›Paper›PMID 23360836›Full record

ReviewClinical immunology (Orlando, Fla.)2013

Immunopathogenesis of osteoarthritis.

Abdul Haseeb, Tariq M Haqqi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical immunology (Orlando, Fla.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Synovial cytokine expression in ankle osteoarthritis depends on age and stage.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015
    Trial
  12. Article
  13. Article
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  15. Article
  16. Review
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  18. Identification of Antibodies to Chondrocyte and Synoviocyte Antigens in Equine Osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
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  19. Article
  20. Article

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Abdul HaseebDepartment of Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Tariq M Haqqi

Funding

Suppression of MMP-13 Expression in Arthritis by PomegranateR01AT005520 · NCCIH · NORTHEAST OHIO MEDICAL UNIVERSITY · PI HAQQI, TARIQ M · 2010 to 2014
$1.9M
MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACTR01AT003627 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HAQQI, TARIQ M · 2007 to 2011
$1.7M
CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACTR21AT004026 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HAQQI, TARIQ M · 2009 to 2010
$255k
NCCIH NIH HHS R01 AT003627NCCIH NIH HHS R01 AT005520NCCIH NIH HHS R21 AT004026
6 · The paper itself

Abstract

Even though osteoarthritis (OA) is mainly considered as a degradative condition of the articular cartilage, there is increasing body of data demonstrating the involvement of all branches of the immune system. Genetic, metabolic or mechanical factors cause an initial injury to the cartilage resulting in release of several cartilage specific auto-antigens, which trigger the activation of immune response. Immune cells including T cells, B cells and macrophages infiltrate the joint tissues, cytokines and chemokines are released from different kinds of cells present in the joint, complement system is activated, and cartilage degrading factors such as matrix metalloproteinases (MMPs) and prostaglandin E2 (PGE2) are released, resulting in further damage to the articular cartilage. There is considerable success in the treatment of rheumatoid arthritis using anti-cytokine therapies. In OA, however, these therapies did not show much effect, highlighting more complex nature of pathogenesis of OA. This needs the development of more novel approaches to treat OA, which may include therapies that act on multiple targets. Plant natural products have this kind of property and may be considered for future drug development efforts. Here we reviewed the studies implicating different components of the immune system in the pathogenesis of OA.

Indexed as

Adaptive ImmunityAnimalsHumansImmunity, InnateOsteoarthritisSignal Transduction

Identifiers

PMID23360836
PMCPMC4015466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.