ArticleAmerican journal of physiology. Endocrinology and metabolism2013
CaSR-mediated interactions between calcium and magnesium homeostasis in mice.
Article in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Identifying risk factors for postoperative hypocalcemia in primary hyperparathyroidism: 12-year experience in a tertiary hospital.Gland surgery · 2026Article
- Minerals and Human Health: From Deficiency to Toxicity.Nutrients · 2025Review
- Calcium and vitamin D substitution for hypoparathyroidism after thyroidectomy - how is it continued after discharge from hospital?Langenbeck's archives of surgery · 2024Article
- Physiological changes in the regulation of calcium and phosphorus utilization that occur after the onset of egg production in commercial laying hens.Frontiers in physiology · 2024Article
- Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.Journal of agricultural and food chemistry · 2023Article
- Molecular insights into mineralotropic hormone inter-regulation.Frontiers in endocrinology · 2023Review
- Magnesium Status and Calcium/Magnesium Ratios in a Series of Cystic Fibrosis Patients.Nutrients · 2022Article
- PTH and FGF23 Exert Interdependent Effects on Renal Phosphate Handling: Evidence From Patients With Hypoparathyroidism and Hyperphosphatemic Familial Tumoral Calcinosis Treated With Synthetic Human PTH 1-34.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- The Role of Disturbed Mg Homeostasis in Chronic Kidney Disease Comorbidities.Frontiers in cell and developmental biology · 2020Review
- Review
- Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.Science advances · 2016Article
- Magnesium and cardiovascular complications of chronic kidney disease.Nature reviews. Nephrology · 2015Review
- Magnesium in CKD: more than a calcification inhibitor?Journal of nephrology · 2015Review
- The calcium-sensing receptor in bone--mechanistic and therapeutic insights.Nature reviews. Endocrinology · 2015Review
- Importance of Ca(2+) in gastric epithelial restitution-new views revealed by real-time in vivo measurements.Current opinion in pharmacology · 2014Review
- Evaluation of 25(OH) Vitamin D3 with Reference to Magnesium Status and Insulin Resistance in T2DM.Journal of clinical and diagnostic research : JCDR · 2013Article
- FGF-23 and secondary hyperparathyroidism in chronic kidney disease.Nature reviews. Nephrology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Calcium (Ca) and magnesium (Mg) homeostasis are interrelated and share common regulatory hormones, including parathyroid hormone (PTH) and vitamin D. However, the role of the calcium-sensing receptor (CaSR) in Mg homeostasis in vivo is not well understood. We sought to investigate the interactions between Mg and Ca homeostasis using genetic mouse models with targeted inactivation of PTH (PTH KO) or both PTH and the calcium-sensing receptor (CaSR) (double knockout, DKO). Serum Mg is lower in PTH KO and DKO mice than in WT mice on standard chow, whereas supplemental dietary Ca leads to equivalent Mg levels for all three genotypes. Mg loading increases serum Mg in all genotypes; however, the increase in serum Mg is most pronounced in the DKO mice. Serum Ca is increased with Mg loading in the PTH KO and DKO mice but not in the WT mice. Here, too, the hypercalcemia is much greater in the DKO mice. Serum and especially urinary phosphate are reduced during Mg loading, which is likely due to intestinal chelation of phosphate by Mg. Mg loading decreases serum PTH in WT mice and increases serum calcitonin in both WT and PTH KO mice but not DKO mice. Furthermore, Mg loading elevates serum 1,25-dihydroxyvitamin D in all genotypes, with greater effects in PTH KO and DKO mice, possibly due to reduced levels of serum phosphorus and FGF23. These hormonal responses to Mg loading and the CaSR's role in regulating renal function may help to explain changes in serum Mg and Ca found during Mg loading.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.