ArticleVirology journal2013
Lineage shift in Indian strains of Dengue virus serotype-3 (Genotype III), evidenced by detection of lineage IV strains in clinical cases from Kerala.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dengue infection in India: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2018Pooled it
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- Evolutionary dynamics and impact of genetic diversity of co-circulating multiple dengue serotypes among severe and non-severe cases in Kolkata, Eastern India during 2020-2022.Archives of microbiology · 2026Article
- A systematic review and meta-analysis of mosquito arboviral infections detected through xenosurveillance in Africa: A focus on West Nile, Rift Valley fever, and chikungunya virus infections.Current research in parasitology & vector-borne diseases · 2026Review
- Prevalence of Different Dengue Serotypes in Northern India, 2021-2022: A Tertiary Care Hospital-Based Study.The American journal of tropical medicine and hygiene · 2025Observational
- Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Molecular Characterization and Identification of Potential Inhibitors for 'E' Protein of Dengue Virus.Viruses · 2022Article
- Emergence of Dengue 4 as Dominant Serotype During 2017 Outbreak in South India and Associated Cytokine Expression Profile.Frontiers in cellular and infection microbiology · 2021Article
- Evolution of Subgenomic RNA Shapes Dengue Virus Adaptation and Epidemiological Fitness.iScience · 2019Article
- Development of a Prognostic Prediction Model to Determine Severe Dengue in Children.Indian journal of pediatrics · 2018Article
- Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil.PLoS neglected tropical diseases · 2018Article
- Complete assembly of a dengue virus type 3 genome from a recent genotype III clade by metagenomic sequencing of serum.Wellcome open research · 2018Article
- Evolutionary history and spatio-temporal dynamics of dengue virus serotypes in an endemic region of Colombia.PloS one · 2018Article
- Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa.Frontiers in genetics · 2018Review
- Co-circulation and co-infections of all dengue virus serotypes in Hyderabad, India 2014.Epidemiology and infection · 2017Article
- Dengue virus serotype 3 and Chikungunya virus co-infection in a traveller returning from India to Portugal, November 2016.IDCases · 2017Article
- Evolutionary Analysis of Dengue Serotype 2 Viruses Using Phylogenetic and Bayesian Methods from New Delhi, India.PLoS neglected tropical diseases · 2016Article
- Lineage shift of dengue virus in Eastern India: an increased implication for DHF/DSS.Epidemiology and infection · 2015Article
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Abstract
backgroundLocal epidemiology of Dengue is defined by the genetic diversity of the circulating Dengue virus (DENV) strains. This important information is not available for the virus strains from most parts of the Indian subcontinent. The present study focused on the genetic diversity of the serotype 3 DENV strains (DENV-3) from India.
resultsA total of 22 DENV-3 strains identified by reverse-transcription PCR analysis of serum samples from 709 patients were studied. These samples were collected over a period of 4 years (2008-2011) from dengue fever suspected patients from Kerala, a dengue endemic state in South India. Comparison of a 1740bp nucleotide sequence of the viral Capsid-Pre-membrane-Envelope coding region of our strains and previously reported DENV-3 strains from India, South Asia and South America revealed non-synonymous substitutions that were genotype III-specific as well as sporadic. Evidence of positive selection was detected in the I81 amino acid residue of the envelope protein. Out of the 22 samples, three had I81A and 18 had I81V substitutions. In the phylogenetic analysis by maximum likelihood method the strains from Kerala clustered in two different lineages (lineage III and IV) within genotype III clade of DENV-3 strains. The ten strains that belonged to lineage IV had a signature amino acid substitution T219A in the envelope protein. Interestingly, all these strains were found to be closely related to a Singapore strain GU370053 isolated in 2007.
conclusionsOur study identifies for the first time the presence of lineage IV strains in the Indian subcontinent. Results indicate the possibility of a recent exotic introduction and also a shift from the existing lineage III strains to lineage IV. Lineage shifts in DENV-3 strains have been attributed to dramatic increase in disease severity in many parts of the world. Hence the present observation could be significant in terms of the clinical severity of future dengue cases in the region.
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