ArticleGenome biology2013
Accelerated exon evolution within primate segmental duplications.
Article in Genome biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Genomic structural variation: A complex but important driver of human evolution.American journal of biological anthropology · 2023Review
- Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta).PLoS genetics · 2020Article
- Gene Fusions Derived by Transcriptional Readthrough are Driven by Segmental Duplication in Human.Genome biology and evolution · 2019Article
- Effect of Collapsed Duplications on Diversity Estimates: What to Expect.Genome biology and evolution · 2018Article
- The value of new genome references.Experimental cell research · 2017Review
- Detection of Pathways Affected by Positive Selection in Primate Lineages Ancestral to Humans.Molecular biology and evolution · 2017Article
- Transcriptome reconstruction and annotation of cynomolgus and African green monkey.BMC genomics · 2014Article
- High order intra-strand partial symmetry increases with organismal complexity in animal evolution.Scientific reports · 2014Article
- Distribution of segmental duplications in the context of higher order chromatin organisation of human chromosome 7.BMC genomics · 2014Article
- Interplay of interlocus gene conversion and crossover in segmental duplications under a neutral scenario.G3 (Bethesda, Md.) · 2014Article
- Comparative primate genomics: emerging patterns of genome content and dynamics.Nature reviews. Genetics · 2014Review
- HIV and innate immunity - a genomics perspective.F1000prime reports · 2013Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe identification of signatures of natural selection has long been used as an approach to understanding the unique features of any given species. Genes within segmental duplications are overlooked in most studies of selection due to the limitations of draft nonhuman genome assemblies and to the methodological reliance on accurate gene trees, which are difficult to obtain for duplicated genes.
resultsIn this work, we detected exons with an accumulation of high-quality nucleotide differences between the human assembly and shotgun sequencing reads from single human and macaque individuals. Comparing the observed rates of nucleotide differences between coding exons and their flanking intronic sequences with a likelihood-ratio test, we identified 74 exons with evidence for rapid coding sequence evolution during the evolution of humans and Old World monkeys. Fifty-five percent of rapidly evolving exons were either partially or totally duplicated, which is a significant enrichment of the 6% rate observed across all human coding exons.
conclusionsOur results provide a more comprehensive view of the action of selection upon segmental duplications, which are the most complex regions of our genomes. In light of these findings, we suggest that segmental duplications could be subjected to rapid evolution more frequently than previously thought.
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