Trial reportEchocardiography (Mount Kisco, N.Y.)2013
Relationship of multidirectional myocardial strain with radial thickening and ejection fraction and impact of left ventricular hypertrophy: a study in a community-based cohort.
Trial report in Echocardiography (Mount Kisco, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic implications of left ventricular strain by speckle-tracking echocardiography in the general population: a meta-analysis.Vascular health and risk management · 2019Pooled it
- Mechanical signatures of left ventricular ejection fraction and mass index in a community cohort (ACE 1950).The international journal of cardiovascular imaging · 2026Article
- Prognostic value and time course evolution left ventricular global longitudinal strain in septic shock: an exploratory prospective study.Journal of clinical monitoring and computing · 2021Observational
- Epidemiology of right ventricular systolic dysfunction in patients with sepsis and septic shock in the emergency department.Internal and emergency medicine · 2020Observational
- Myocardial Microvascular Dysfunction in Rheumatoid ArthritisCirculation. Cardiovascular imaging · 2019Article
- Myocardial Inflammation, Measured Using 18-Fluorodeoxyglucose Positron Emission Tomography With Computed Tomography, Is Associated With Disease Activity in Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Observational
- Subclinical Compromise in Cardiac Strain Relates to Lower Cognitive Performances in Older Adults.Journal of the American Heart Association · 2018Article
- SOFA score and left ventricular systolic function as predictors of short-term outcome in patients with sepsis.Internal and emergency medicine · 2018Article
- Extra-cellular expansion in the normal, non-infarcted myocardium is associated with worsening of regional myocardial function after acute myocardial infarction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Article
- Relationship of Office and Ambulatory Blood Pressure With Left Ventricular Global Longitudinal Strain.American journal of hypertension · 2016Article
- Atrial fibrillation per se was a major determinant of global left ventricular longitudinal systolic strain.Medicine · 2016Article
- Left Ventricular Systolic Function Changes in Primary Hypertension Patients Detected by the Strain of Different Myocardium Layers.Medicine · 2016Article
- Left Ventricular Systolic Dysfunction by Longitudinal Strain Is an Independent Predictor of Incident Atrial Fibrillation: A Community-Based Cohort Study.Circulation. Cardiovascular imaging · 2015Article
- Prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global longitudinal strain in a community-based cohort.European journal of heart failure · 2014Article
- Subclinical left ventricular dysfunction and silent cerebrovascular disease: the Cardiovascular Abnormalities and Brain Lesions (CABL) study.Circulation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundLeft ventricular (LV) systolic strain provides additional prognostic value to LV ejection fraction (LVEF) and wall motion analysis. However, the relationship between myocardial multidirectional strain and LVEF, and the effect of LV hypertrophy on this relationship, are not completely understood especially in unselected populations.
methodsLV global longitudinal (εL ) and circumferential (εC ) systolic strain analysis was performed by two-dimensional speckle tracking echocardiography in 215 participants from a community-based study. LV radial wall thickening was measured as global radial strain (εR ), and LVEF was assessed by biplane Simpson's method.
resultsεR was significantly associated with εC (β = -0.56, P < 0.01) and with εL (β = -0.18, P < 0.01). The contribution of εL to εR was especially evident in subjects with lower εC and in presence of LV hypertrophy (β = -0.30, P < 0.01). εL and εC were significantly associated with LVEF (β = -0.36 and β = -0.49, both P < 0.01) independent of LV mass and other confounders, and their interaction significantly improved the prediction of LVEF (R(2) -change = 0.14) but not of εR (R(2) -change = 0.002).
conclusionsεR is mainly related to εC with a smaller contribution of εL , which becomes especially evident in subjects with lower εC and in presence of LV hypertrophy. Therefore, radial thickening may not detect subclinical LV longitudinal function reduction in normal ventricles and when εC is preserved. While a reduction in εL has a limited impact on εR , it exerts a greater effect on global LVEF, therefore for a more accurate LVEF prediction both εL and εC need to be considered.
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