ArticleCardiovascular diabetology2013
Temporal changes in concentrations of lipids and apolipoprotein B among adults with diagnosed and undiagnosed diabetes, prediabetes, and normoglycemia: findings from the National Health and Nutrition Examination Survey 1988-1991 to 2005-2008.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Assessment of Dyslipidemia, Lipid Ratios, and Atherogenic Indices as Cardiovascular Risk Factors in Prediabetic and Diabetic Subjects.Journal of laboratory physicians · 2022Article
- Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus-The Tromsø study.Endocrinology, diabetes & metabolism · 2022Article
- Tracking lipid profile and atherogenic indices in the prediabetics of Andaman Nicobar Islands: A retrospective hospital-based study.Journal of family medicine and primary care · 2019Article
- Sick Individuals and Sick Populations by Geoffrey Rose: Cardiovascular Prevention Updated.Journal of the American Heart Association · 2018Review
- PROMETHEUS: an observational, cross-sectional, retrospective study of hypertriglyceridemia in Russia.Cardiovascular diabetology · 2015Observational
- Awareness, treatment and control of cardiometabolic disorders in Chinese adults with diabetes: a national representative population study.Cardiovascular diabetology · 2015Article
- Declines in coronary heart disease incidence and mortality among middle-aged adults with and without diabetes.Annals of epidemiology · 2014Article
- Significant associations between lipoprotein(a) and corrected apolipoprotein B-100 levels in African-Americans.Atherosclerosis · 2014Article
- Trends in cardiovascular disease risk factors in people with and without diabetes mellitus: a Middle Eastern cohort study.PloS one · 2014Article
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3 authors at 2 institutions in 2 countries.
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Abstract
backgroundDiabetes is characterized by profound lipid abnormalities. The objective of this study was to examine changes in concentrations of lipids and apolipoprotein B among participants stratified by glycemic status (diabetes, undiagnosed diabetes, prediabetes, and normoglycemia) in the United States from 1988-1991 to 2005-2008.
methodsWe used data from 3202 participants aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) III (1988-1991) and 3949 participants aged ≥20 years from NHANES 2005-2008.
resultsAmong participants of all four groups, unadjusted and adjusted mean concentrations of total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B, but not triglycerides, decreased significantly. Among participants with prediabetes and normoglycemia, unadjusted and adjusted mean concentrations of high-density lipoprotein cholesterol increased significantly. Adjusted mean log-transformed concentrations of triglycerides decreased in adults with undiagnosed diabetes and prediabetes. During 2005-2008, unadjusted concentrations of apolipoprotein B ≥80 mg/dl were observed in 72.8% of participants with diagnosed diabetes, 87.9% of participants with undiagnosed diabetes, 86.6% of participants with prediabetes, and 77.2% of participants with normoglycemia. The unadjusted use of cholesterol-lowering medications rose rapidly, especially among participants with diabetes (from ~1% to ~49%, P <0.001). The use of fenofibrate, gemfibrozil, and niacin rose significantly only among adults with diagnosed diabetes (from ~2% to ~8%, P = 0.011).
conclusionLipid profiles of adults with diabetes improved during the approximately 16-year study period. Nevertheless, large percentages of adults continue to have elevated concentrations of apolipoprotein B.
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