Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.
Ji Qian, Hongliang Liu, Sheng Wei, Zhensheng Liu, Yangkai Li, Li-E Wang, Wei V Chen, Christopher I Amos, Jeffrey E Lee, GenoMEL investigators and 13 more
Article in Pigment cell & melanoma research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
23 authors at 5 institutions in 3 countries.
Ji QianDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hongliang Liu
Sheng Wei
Zhensheng Liu
Yangkai Li
Li-E Wang
Wei V Chen
Christopher I Amos
Jeffrey E Lee
GenoMEL investigators
Mark M Iles
Matthew H Law
Q-MEGA AMFS investigators
Anne E Cust
Jennifer H Barrett
Grant W Montgomery
John Taylor
Julia A Newton Bishop
Stuart Macgregor
D Timothy Bishop
Graham J Mann
Nicholas K Hayward
Qingyi Wei
The University of Texas MD Anderson Cancer Center · USQIMR Berghofer Medical Research Institute · AUCancer Research UK · GBThe University of Sydney · AUDartmouth College · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
UT M.D. Anderson Cancer Center SPORE in MelanomaP50CA093459 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GRIMM, ELIZABETH A · 2004 to 2014
$23.7M
Genetic Epidermiology of MelanomaR01CA083115 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BISHOP, DAVID TIMOTHY, ELDER, DAVID ERIC · 2001 to 2017
$13.0M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Molecular Epidemiology of Head and Neck CancerR01ES011740 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2001 to 2012
$6.3M
BIOCHEMICAL MARKERS IN THE NURSES HEALTH STUDY COHORTU01CA049449 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI HANKINSON, SUSAN E · 1995 to 2013
$5.4M
Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck CancerR01CA131274 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2009 to 2013
$3.0M
Pathways from genotype and environment to melanomaR01CA088363 · NCI · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI HAYWARD, NICHOLAS K · 2001 to 2012
$2.4M
Genetic Predictors for DNA Repair Phenotype in CMMR01CA100264 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2004 to 2008
$1.5M
Cohort Study of Genetic Susceptibility to Cutaneous Malignant MelanomaR01CA122838 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HAN, JIALI · 2008 to 2010
$1.4M
Cancer Research UK 10589Cancer Research UK C588/A10589Cancer Research UK C588/A4994Cancer Research UK C8216/A6129NCI NIH HHS CA83115NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA093459NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA083115NCI NIH HHS R01 CA088363NCI NIH HHS R01 CA100264NCI NIH HHS R01 CA122838NCI NIH HHS R01 CA131274NCI NIH HHS R01CA131274NCI NIH HHS R01 CA133996NCI NIH HHS U01 CA049449NHGRI NIH HHS HHSN268200782096CNIEHS NIH HHS R01 ES011740NIEHS NIH HHS R01ES011740Wellcome Trust
6 · The paper itself
Abstract
To mine possibly hidden causal single-nucleotide polymorphisms (SNPs) of melanoma, we investigated the association of SNPs in 76 M/G1 transition genes with melanoma risk using our published genome-wide association study (GWAS) data set with 1804 melanoma cases and 1026 cancer-free controls. We found multiple SNPs with P < 0.01 and performed validation studies for 18 putative functional SNPs in PSMB9 in two other GWAS data sets. Two SNPs (rs1351383 and rs2127675) were associated with melanoma risk in the GenoMEL data set (P = 0.013 and 0.004, respectively), but failed in validation using the Australian data set. Genotype-phenotype analysis revealed these two SNPs were significantly correlated with mRNA expression level of PSMB9. Further experiments revealed that SNP rs2071480, which is in high LD with rs1351383 and rs2127675, may have a weak effect on the promoter activity of PSMB9. Taken together, our data suggested that functional variants in PSMB9 may contribute to melanoma susceptibility.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyPublicationsAustraliaBase SequenceCase-Control StudiesCell CycleCysteine EndopeptidasesGene Expression Regulation, NeoplasticHumansMelanomaMolecular Sequence DataPolymorphism, Single NucleotidePromoter Regions, GeneticReproducibility of ResultsRisk FactorsCysteine EndopeptidasesLMP-2 proteinRNA, Messenger
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies. · full record | OpenQuestion