ArticleeLife2013
Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Irregular and bursty neuronal firing extend spike-timing dependent plasticity window to behavioral timescales.iScience · 2026Article
- A neuroprosthesis for restoring hand movement and sensation in a person with complete tetraplegia.Nature medicine · 2026Article
- Dorsal root ganglion neuromodulation restores accumbal gate to inhibit mechanical allodynia.The journal of headache and pain · 2026Article
- Repetitive Sensory Stimulation Potentiates and Recruits Sensory-Evoked Cortical Population Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Wired together, change together: Spike timing modifies transmission in converging assemblies.Science advances · 2024Article
- Neural Field Continuum Limits and the Structure-Function Partitioning of Cognitive-Emotional Brain Networks.Biology · 2023Review
- Impact of functional synapse clusters on neuronal response selectivity.Nature communications · 2020Article
- Locally coordinated synaptic plasticity of visual cortex neurons in vivo.Science (New York, N.Y.) · 2018Article
- Robustness of STDP to spike timing jitter.Scientific reports · 2018Article
- Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo.Neuron · 2018Article
- Control of synaptic plasticity in deep cortical networks.Nature reviews. Neuroscience · 2018Review
- From single cells and single columns to cortical networks: dendritic excitability, coincidence detection and synaptic transmission in brain slices and brains.Experimental physiology · 2017Review
- Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells.Nature communications · 2016Article
- Dendritic integration: 60 years of progress.Nature neuroscience · 2015Review
- Synaptic plasticity as a cortical coding scheme.Current opinion in neurobiology · 2015Review
- Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex.Nature neuroscience · 2015Article
- Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning.eLife · 2015Article
- Plasticity of cortical excitatory-inhibitory balance.Annual review of neuroscience · 2015Review
- How to train a neuron.eLife · 2013Article
- Topological dynamics in spike-timing dependent plastic model neural networks.Frontiers in neural circuits · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Action Potential (APs) patterns of sensory cortex neurons encode a variety of stimulus features, but how can a neuron change the feature to which it responds? Here, we show that in vivo a spike-timing-dependent plasticity (STDP) protocol-consisting of pairing a postsynaptic AP with visually driven presynaptic inputs-modifies a neurons' AP-response in a bidirectional way that depends on the relative AP-timing during pairing. Whereas postsynaptic APs repeatedly following presynaptic activation can convert subthreshold into suprathreshold responses, APs repeatedly preceding presynaptic activation reduce AP responses to visual stimulation. These changes were paralleled by restructuring of the neurons response to surround stimulus locations and membrane-potential time-course. Computational simulations could reproduce the observed subthreshold voltage changes only when presynaptic temporal jitter was included. Together this shows that STDP rules can modify output patterns of sensory neurons and the timing of single-APs plays a crucial role in sensory coding and plasticity.DOI:http://dx.doi.org/10.7554/eLife.00012.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.