ArticlePloS one2013
Both serum apolipoprotein B and the apolipoprotein B/apolipoprotein A-I ratio are associated with carotid intima-media thickness.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D.Journal of lipid research · 2019Trial
- Apolipoprotein B/A1 Ratio Improves Discrimination of Severe Atherosclerosis Beyond Conventional Lipid Markers in High-Risk Statin-Naive Patients.Journal of clinical medicine · 2026Article
- The Association between Apolipoprotein B, Cardiovascular Risk Factors and Subclinical Atherosclerosis-Findings from the SEPHAR National Registry on Hypertension in Romania.International journal of molecular sciences · 2023Article
- Apolipoproteins as potential communicators play an essential role in the pathogenesis and treatment of early atherosclerosis.International journal of biological sciences · 2023Review
- Review
- Sex-specific differences in blood lipids and lipid ratios in type 2 diabetic foot patients.Journal of diabetes investigation · 2021Article
- Relationship of Apolipoproteins with Subclinical Cardiovascular Risk in Youth.The Journal of pediatrics · 2020Article
- [Correlation of apolipoprotein AI, apolipoprotein B and their ratio with the severity of cerebral white matter lesions].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Apolipoprotein B/apolipoprotein A1 ratio and mortality among incident peritoneal dialysis patients.Lipids in health and disease · 2018Article
- Sini Decoction Intervention on AtherosclerosisOpen life sciences · 2018Article
- Features and risk factors of carotid atherosclerosis in a population with high stroke incidence in China.Oncotarget · 2017Article
- High prevalence of subclinical atherosclerosis in Brazilian postmenopausal women with low and intermediate risk by Framingham score.The international journal of cardiovascular imaging · 2017Article
- Carotid Intima-media Thickness and its Association with Conventional Risk Factors in Low-income Adults: A Population-based Cross-Sectional Study in China.Scientific reports · 2017Article
- Impact of menopause and diabetes on atherogenic lipid profile: is it worth to analyse lipoprotein subfractions to assess cardiovascular risk in women?Diabetology & metabolic syndrome · 2017Review
- Observational
- The value of the apoB/apoAΙ ratio and the non-HDL-C/HDL-C ratio in predicting carotid atherosclerosis among Chinese individuals with metabolic syndrome: a cross-sectional study.Lipids in health and disease · 2015Article
- High levels of LDL-C combined with low levels of HDL-C further increase platelet activation in hypercholesterolemic patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies indicated that apolipoprotein measurements predicted cardiovascular disease (CVD) risk; however, associations between apolipoproteins and carotid intima-media thickness (CIMT) were less explored. METHODOLOGY AND PRINCIPAL
findingsThe cross-sectional study included 6069 participants aged 40 years or older with NGT from Shanghai, China. Serum fasting traditional lipids (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C] and triglycerides [TG]), apoA-I and apoB were assessed. A high-resolution B-mode ultrasonography was performed to measure CIMT. We found CIMT increased progressively across the quartiles of serum apoB (p for trend <0.0001). In logistic regression, concentrations of apoB (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.18-1.36), TC (OR 1.23, 95% CI 1.14-1.32), LDL-C (OR 1.25, 95% CI 1.16-1.34) and TG (OR 1.11, 95% CI 1.04-1.20) were significantly related to elevated CIMT after adjusted for age and sex. Meanwhile, the apoB/apoA-I ratio (OR 1.25, 95% CI 1.17-1.34) related to elevated CIMT. ApoB (OR 1.23, 95% CI 1.00-1.51) and the apoB/apoA-I ratio (OR 1.19, 95% CI 1.04-1.36) remained significantly associated with elevated CIMT, after adjusted for the traditional CVD risk factors including traditional lipids. CONCLUSIONS AND SIGNIFICANCE: There were significant associations between serum apoB, the apoB/apoA-I ratio and elevated CIMT. Serum apoB and the apoB/apoA-I ratio might be independent predictors of early atherosclerosis in NGT.
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