ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2012
The efficacy of the inhalation of an aerosolized Group A streptococcal preparation in the treatment of lung cancer.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Effects of programmed death-ligand 1 expression on OK-432 immunotherapy following transurethral resection in non-muscle invasive bladder cancer.Oncology letters · 2017Article
- MicroRNA‑21 regulates the expression of BTG2 in HepG2 liver cancer cells.Molecular medicine reports · 2015Article
- Expression and significance of miRNA-21 and BTG2 in lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
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6 authors.
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Abstract
objectiveTo observe the efficacy of the inhalation of an aerosolized group A streptococcal (GAS) preparation in treating orthotopic lung cancer in mouse models and assess the feasibility, safety, and effectiveness of this administration mode for lung cancer.
methodsLewis lung carcinoma (LLC) cell strains were administered via intrathoracic injection to establish orthotopic lung cancer mouse models. After the tumor-bearing models were successfully established, as confirmed by computed tomography, the mice were administered by inhalation with an aerosolized GAS preparation (GAS group) or aerosolized normal saline (control group). The anti-tumor effect of the aerosolized GAS preparation was evaluated histologically; meanwhile, the survival and quality of life were compared between these two groups.
resultsThe aerosolized GAS preparation showed remarkably anti-tumor effect, causing the necrosis of the orthotopic lung cancer cells in tumor-bearing mice. Furthermore, mice in the GAS group had significantly better quality of life and longer survival than those in control group.
conclusionsThe inhalation of aerosolized GAS preparation may be a feasible, safe and effective solution for lung cancer.
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