ArticleProceedings of the National Academy of Sciences of the United States of America2013
Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Modeling inducible neuropathologies of the retina with differential phenotypes in organoids.Frontiers in cellular neuroscience · 2023Article
- A Potential Role of Cyclic Dependent Kinase 1 (CDK1) in Late Stage of Retinal Degeneration.Cells · 2022Article
- Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Efficacy.International journal of molecular sciences · 2021Article
- Inhibition of Epigenetic Modifiers LSD1 and HDAC1 Blocks Rod Photoreceptor Death in Mouse Models of Retinitis Pigmentosa.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Migration of pre-induced human peripheral blood mononuclear cells from the transplanted to contralateral eye in mice.Stem cell research & therapy · 2021Article
- Mouse Retinal Organoid Growth and Maintenance in Longer-Term Culture.Frontiers in cell and developmental biology · 2021Article
- ERG Responses in Mice with Deletion of the Synaptic Ribbon Component RIBEYE.Investigative ophthalmology & visual science · 2020Article
- AnFrontiers in neuroscience · 2020Article
- Mechanisms of neurodegeneration in a preclinical autosomal dominant retinitis pigmentosa knock-in model with a RhoCellular and molecular life sciences : CMLS · 2019Article
- DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice.Cell death & disease · 2018Article
- Tissue inhibitor of metalloproteinases 1 enhances rod survival in the rd1 mouse retina.PloS one · 2018Article
- E2f1 mediates high glucose-induced neuronal death in cultured mouse retinal explants.Cell cycle (Georgetown, Tex.) · 2017Article
- Proteomic profiling of early degenerative retina of RCS rats.International journal of ophthalmology · 2017Article
- Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations.BMC genomics · 2016Article
- Epigenetics and therapeutic targets mediating neuroprotection.Brain research · 2015Review
- A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa.Nature communications · 2015Article
- Roscovitine in cancer and other diseases.Annals of translational medicine · 2015Review
- DNA methylation and differential gene regulation in photoreceptor cell death.Cell death & disease · 2014Article
- Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epigenetic regulator Bmi1 controls proliferation in many organs. Reexpression of cell cycle proteins such as cyclin-dependent kinases (CDKs) is a hallmark of neuronal apoptosis in neurodegenerative diseases. Here we address the potential role of Bmi1 as a key regulator of cell cycle proteins during neuronal apoptosis. We show that several cell cycle proteins are expressed in different models of retinal degeneration and required in the Rd1 photoreceptor death process. Deleting E2f1, a downstream target of CDKs, provided temporary protection in Rd1 mice. Most importantly, genetic ablation of Bmi1 provided extensive photoreceptor survival and improvement of retinal function in Rd1 mice, mediated by a decrease in cell cycle markers and regulators independent of p16(Ink4a) and p19(Arf). These data reveal that Bmi1 controls the cell cycle-related death process, highlighting this pathway as a promising therapeutic target for neuroprotection in retinal dystrophies.
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