ArticlePediatrics2013
Guidance on management of asymptomatic neonates born to women with active genital herpes lesions.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- Sexually transmitted diseases treatment guidelines, 2015.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2015Guideline
- Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients.The Cochrane database of systematic reviews · 2014Pooled it
- Genital Herpes Simplex Virus (HSV) Infection During Pregnancy - Recommendations of the Working Group on Obstetrics and Prenatal Medicine (AGG - Section on Maternal Disorders).Geburtshilfe und Frauenheilkunde · 2026Article
- Maternal-Fetal Implications of Herpes Virus Infection: An Updated Review.Diagnostics (Basel, Switzerland) · 2026Review
- Congenital HSV-2 infection with atypical skin lesions, chorioretinitis, and neurodevelopmental sequelae: a case report.BMC pregnancy and childbirth · 2026Article
- A Multicenter Study on Symptomatic Neonatal Herpes Simplex Virus Infection in Korea From 2008 to 2017.Journal of Korean medical science · 2025Article
- The Incidence of Neonatal Herpes Simplex Virus Infections in the United States: 2019.Pediatrics · 2025Article
- Neonatal herpes: case series in two obstetric centres over a 10-year period (2013-2023), France.European journal of pediatrics · 2024Article
- Seroprevalence of Herpes Simplex Virus Types 1 and 2 among Pregnant Women in South-Western Romania.Life (Basel, Switzerland) · 2024Article
- Article
- Characteristics of neonatal herpes simplex virus infections in Germany: results of a 2-year prospective nationwide surveillance study.Archives of disease in childhood. Fetal and neonatal edition · 2022Article
- Immunoregulatory Functions of Interferons During Genital HSV-2 Infection.Frontiers in immunology · 2021Review
- Inborn Errors of Immunity in the Premature Infant: Challenges in Recognition and Diagnosis.Frontiers in immunology · 2021Review
- Prevention and treatment of neonatal herpes simplex virus infection.Antiviral research · 2020Review
- Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at delivery.IDCases · 2020Article
- Laboratory Diagnosis of Neonatal Herpes Simplex Virus Infections.Journal of clinical microbiology · 2019Review
- Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Comparison of Herpes Simplex Virus PCR with Culture for Virus Detection in Multisource Surface Swab Specimens from Neonates.Journal of clinical microbiology · 2018Article
- Encephalitis in US Children.Infectious disease clinics of North America · 2018Review
- Effectiveness of Early Antiviral Therapy in Disseminated Neonatal Herpes Simplex Virus 2 (HSV-2) with Fulminant Hepatic Failure.The American journal of case reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Herpes simplex virus (HSV) infection of the neonate is uncommon, but genital herpes infections in adults are very common. Thus, although treating an infant with neonatal herpes is a relatively rare occurrence, managing infants potentially exposed to HSV at the time of delivery occurs more frequently. The risk of transmitting HSV to an infant during delivery is determined in part by the mother's previous immunity to HSV. Women with primary genital HSV infections who are shedding HSV at delivery are 10 to 30 times more likely to transmit the virus to their newborn infants than are women with recurrent HSV infection who are shedding virus at delivery. With the availability of commercial serological tests that reliably can distinguish type-specific HSV antibodies, it is now possible to determine the type of maternal infection and, thus, further refine management of infants delivered to women who have active genital HSV lesions. The management algorithm presented herein uses both serological and virological studies to determine the risk of HSV transmission to the neonate who is delivered to a mother with active herpetic genital lesions and tailors management accordingly. The algorithm does not address the approach to asymptomatic neonates delivered to women with a history of genital herpes but no active lesions at delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.