ArticleAmerican journal of cancer research2013
Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages.
Article in American journal of cancer research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 65 citations in OpenAlex.
- Myeloid-Derived Suppressor Cells (MDSCs) and Obesity-Induced Inflammation in Type 2 Diabetes.Diagnostics (Basel, Switzerland) · 2024Review
- Effects of an environmentally relevant mixture of organochlorine pesticide compounds on adipogenesis and adipocyte function in an immortalized human adipocyte model.Toxicology in vitro : an international journal published in association with BIBRA · 2024Article
- The causal effect of adipose tissue on Hodgkin's lymphoma: two-sample Mendelian randomization study and validation.Frontiers in immunology · 2024Article
- Effects of Lactic Acid Bacteria Isolated from Equine on Salmonella-Infected Gut Mouse Model.Probiotics and antimicrobial proteins · 2023Article
- Metagenomic and Untargeted Metabolomic Analysis of the Effect ofFoods (Basel, Switzerland) · 2023Article
- The Roles of Innate Lymphoid Cells in the Gastric Mucosal Immunology and Oncogenesis of Gastric Cancer.International journal of molecular sciences · 2023Review
- Sex and gender differences in myocarditis and dilated cardiomyopathy: An update.Frontiers in cardiovascular medicine · 2023Review
- The role of obesity and bariatric surgery-induced weight loss in breast cancer.Cancer metastasis reviews · 2022Review
- Breast cancer microenvironment and obesity: challenges for therapy.Cancer metastasis reviews · 2022Review
- Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the "obesity paradox".Frontiers in immunology · 2022Article
- Exploration of biomarkers from a pilot weight management study for men undergoing radical prostatectomy.Urologic oncology · 2021Article
- G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.Cell death & disease · 2021Article
- Obesity-Associated Myeloid Immunosuppressive Cells, Key Players in Cancer Risk and Response to Immunotherapy.Obesity (Silver Spring, Md.) · 2021Review
- Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis.Cancers · 2021Article
- P-cymene prevent high-fat diet-associated colorectal cancer by improving the structure of intestinal flora.Journal of Cancer · 2021Article
- ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease.Journal of molecular medicine (Berlin, Germany) · 2020Review
- High Fat High Calories Diet (HFD) Increase Gut Susceptibility to Carcinogens by Altering the Gut Microbial Community.Journal of Cancer · 2020Article
- Sex differences in pulmonary arterial hypertension: role of infection and autoimmunity in the pathogenesis of disease.Biology of sex differences · 2018Review
- Myeloid-derived suppressor cells coming of age.Nature immunology · 2018Review
- Tumour-adipose tissue crosstalk: fuelling tumour metastasis by extracellular vesicles.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During carcinogenesis, tumors induce dysfunctional development of hematopoietic cells. Myeloid lineage cells, in the form of myeloid derived suppressor cells (MDSCs) and alternatively polarized M2 macrophages, influence almost all types of cancers by regulating diverse facets of immunosuppression, angiogenesis, cell proliferation, growth and metastasis. One-third of Americans are obese, and accumulating evidence suggests that obesity is a risk factor for various cancers. However, the relationship between these immune players and obesity are not well-described. In this review, we evaluate potential mechanisms through which different aspects of obesity, namely insulin resistance, increased estrogen, adiposity and low grade chronic inflammation from adipose tissue macrophages, may coalesce to promote MDSC induction and M2 macrophage polarization, thereby facilitating cancer development. Detailed understanding of the interplay between obesity and myeloid mediated immunosuppression may provide novel avenues for therapeutic targeting, with the goal to reduce the challenge obesity presents towards gains made in cancer outcomes.
Indexed as
Identifiers
23359288PMC3555202W147964936What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.