ArticleJPEN. Journal of parenteral and enteral nutrition2014
Cranberry proanthocyanidins improve intestinal sIgA during elemental enteral nutrition.
Article in JPEN. Journal of parenteral and enteral nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Review
- Protective effect of homogeneous polysaccharides of Wuguchong (HPW) on intestinal mucositis induced by 5-fluorouracil in mice.Nutrition & metabolism · 2022Article
- Preventive effect ofFrontiers in cellular and infection microbiology · 2022Article
- Highly Active Cranberry's Polyphenolic Fraction: New Advances in Processing and Clinical Applications.Nutrients · 2021Review
- Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further.Frontiers in nutrition · 2021Review
- Dietary phytonutrients and animal health: regulation of immune function during gastrointestinal infections.Journal of animal science · 2020Review
- Dietary Taxifolin Protects Against Dextran Sulfate Sodium-Induced ColitisFrontiers in immunology · 2020Article
- Effect ofBioMed research international · 2019Article
- Effect of Sweetened Dried Cranberry Consumption on Urinary Proteome and Fecal Microbiome in Healthy Human Subjects.Omics : a journal of integrative biology · 2018Article
- Dietary feeding of freeze-dried whole cranberry inhibits intestinal tumor development inOncotarget · 2017Article
- Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015.Advances in nutrition (Bethesda, Md.) · 2016Review
- Consumption of sweetened, dried cranberries may reduce urinary tract infection incidence in susceptible women--a modified observational study.Nutrition journal · 2013Observational
- JAK-STAT and intestinal mucosal immunology.JAK-STAT · 2013Review
- Addition of cranberry to proton pump inhibitor-based triple therapy forJournal of research in pharmacy practiceArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundElemental enteral nutrition (EEN) decreases gut-associated lymphoid tissue (GALT) function, including fewer Peyer's patch lymphocytes and lower levels of the tissue T helper 2 (Th2) cytokines and mucosal transport protein polymeric immunoglobulin receptor (pIgR), leading to lower luminal secretory immunoglobulin A (sIgA) levels. Since we recently demonstrated that cranberry proanthocyanidins (PACs) maintain the Th2 cytokine interleukin (IL)-4 when added to EEN, we hypothesized the addition of PACs to EEN would normalize other GALT parameters and maintain luminal levels of sIgA.
methodsInstitute of Cancer Research mice were randomized (12/group) to receive chow, EEN, or EEN + PACs (100 mg/kg body weight) for 5 days, starting 2 days after intragastric cannulation. Ileum tissue was collected to measure IL-4 by enzyme-linked immunosorbent assay, pIgR by Western blot, and phosphorylated STAT-6 by microarray. Intestinal wash fluid was collected to measure sIgA by Western blot.
resultsCompared with chow, EEN significantly decreased tissue IL-4, phosphorylated STAT-6, and pIgR. The addition of PACs to EEN prevented these alterations. Compared with chow, EEN resulted in significantly lower levels of luminal sIgA. The addition of PACs to EEN increased luminal sIgA levels compared with EEN alone.
conclusionsThis study suggests the addition of PACs to EEN may support GALT function and maintain intestinal sIgA levels compared with EEN administration alone.
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