ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2012
Clinicopathological Significance of Mucin 2 Immuno-histochemical Expression in Colorectal Cancer: A Meta-Analysis.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma.BMC gastroenterology · 2024Pooled it
- Construction and validation of prognostic model for colorectal mucinous adenocarcinoma patients and identification of a new prognosis related geneTranslational cancer research · 2024Article
- Upregulated MUC2 Is an Unfavorable Prognostic Indicator for Rectal Cancer Patients Undergoing Preoperative CCRT.Journal of clinical medicine · 2021Article
- Review
- Mucinous colorectal adenocarcinoma: clinical pathology and treatment options.Cancer communications (London, England) · 2019Review
- Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2019Review
- Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2018Review
- Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy.Surgery today · 2017Article
- Advances in the care of patients with mucinous colorectal cancer.Nature reviews. Clinical oncology · 2016Review
- MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis.Journal of pathology and translational medicine · 2015Article
- The molecular background of mucinous carcinoma beyond MUC2.The journal of pathology. Clinical research · 2015Review
- Immunohistochemical study of MUC1, MUC2 and MUC5AC in colorectal carcinoma and review of literature.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Review
- A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study: MUC3 is a novel prognostic factor.PloS one · 2014Article
- Low expression of MUC2 is associated with longer disease-free survival in patients with colorectal carcinoma.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the association between mucin 2 (MUC2) expression and clinicopathological characters of colorectal cancer.
methodsA literature search was performed on December 31, 2010 according to defined selection criteria. We evaluated the correlation between MUC2 (detected by immunohistochemistry) and clinicopathological characters of colorectal cancer. According to the tumor histological type, differentiation, location and TNM staging of colorectal carcinoma, we divided the clinicopathological characteristics into different subgroups. Fixed and random effects models were applied for estimation of the summarized risk ratios (RRs) and 95% confidence intervals (CIs) in different subgroups. Finally, forest plots and funnel plots were created to allow for visual comparison of the results or the effect of publication bias.
resultsAccording with the inclusive criteria, fourteen studies (n=1,558) were eligible for the meta-analysis. We observed a trend towards a correlation of MUC2 higher positivity in mucinous than non-mucinous carcinoma (RR, 2.10; 95% CI, 1.30-3.40; P=0.002) and less positivity in distal than proximal colon (RR, 0.74; 95% CI, 0.64-0.85; P=0.000). There was no statistically significance for the association between MUC2 expression and differentiation or TNM staging of colorectal cancer, but MUC2 overexpression tended to be associated with the presence of T stage tumor (RR, 1.17; P=0.052).
conclusionMUC2 overexpression was associated with the mucinous and proximal colorectal cancer.
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