Trial reportJAMA neurology2013
Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women.
Trial report in JAMA neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- A prospective study of chronic obstructive pulmonary disease and the risk for mild cognitive impairment.JAMA neurology · 2014Trial
- Association of cardiometabolic multimorbidity and high-risk lifestyle behaviours with subjective cognitive decline: baseline findings from the China ageing and health survey.Journal of global health · 2025Article
- Sex Differences in the Impact of Atherosclerotic Cardiovascular Risk Burden on Cognitive Health.Journal of the American Heart Association · 2025Article
- Exercise Delays Brain Ageing Through Muscle-Brain Crosstalk.Cell proliferation · 2025Review
- Association of Atrial Fibrillation and Cognitive Dysfunction: A Comprehensive Narrative Review of Current Understanding and Recent Updates.Journal of clinical medicine · 2024Review
- Multimorbidity measures associated with cognitive function among community-dwelling older Chinese adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients.International journal of environmental research and public health · 2022Review
- Risk of early- and late-onset Alzheimer disease and related dementia in adults with cerebral palsy.Developmental medicine and child neurology · 2022Article
- Sex Differences in the Association Between Midlife Cardiovascular Conditions or Risk Factors With Midlife Cognitive Decline.Neurology · 2022Article
- The Relationship Between Pre-existing Coronary Heart Disease and Cognitive Impairment Is Partly Explained by Reduced Left Ventricular Ejection Fraction in the Subjects Without Clinical Heart Failure: A Cross-Sectional Study.Frontiers in human neuroscience · 2022Article
- Linear vs volume measures of ventricle size: Relation to present and future gait and cognition.Neurology · 2020Article
- Influence of mild cognitive impairment on activities of daily living in patients with cardiovascular disease.Heart and vessels · 2019Article
- Exercise Improves Vascular Function, but does this Translate to the Brain?Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Cognitive dysfunction in atrial fibrillation.Nature reviews. Cardiology · 2018Review
- Regional myocardial motion in patients with mild cognitive impairment: a pilot study.BMC cardiovascular disorders · 2018Article
- Association of body mass index with amnestic and non-amnestic mild cognitive impairment risk in elderly.BMC psychiatry · 2017Article
- Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia.Brain pathology (Zurich, Switzerland) · 2016Review
- Article
- Atrial fibrillation, cognitive impairment, and neuroimaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Article
- Multimorbidity and Risk of Mild Cognitive Impairment.Journal of the American Geriatrics Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate the association of cardiac disease with amnestic and nonamnestic mild cognitive impairment (aMCI and naMCI, respectively). Nonamnestic mild cognitive impairment, a putative precursor of vascular and other non-Alzheimer dementias, is hypothesized to have a vascular etiology.
designA prospective, population-based, cohort study with a median 4.0 years of follow-up.
settingOlmsted County, Minnesota.
participantsA total of 2719 participants were evaluated at baseline and every 15 months using the Clinical Dementia Rating scale, a neurological evaluation, and neuropsychological testing. A diagnosis of normal cognition, MCI, or dementia was made by consensus. Cardiac disease at baseline was assessed from the participant's medical records.
main outcome measuresIncident MCI, aMCI, or naMCI.
resultsOf 1450 participants without MCI or dementia at baseline, 366 developed MCI. Cardiac disease was associated with an increased risk of naMCI (hazard ratio, 1.77 [95% CI, 1.16-2.72]). However, the association varied by sex (P = .02 for interaction). Cardiac disease was associated with an increased risk of naMCI (hazard ratio, 3.07 [95% CI, 1.58-5.99]) for women but not for men (hazard ratio, 1.16 [95% CI, 0.68-1.99]). Cardiac disease was not associated with any type of MCI or with aMCI.
conclusionsCardiac disease is an independent risk factor for naMCI; within-sex comparisons showed a stronger association for women. Prevention and management of cardiac disease and vascular risk factors may reduce the risk of naMCI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.