ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2012
Pathologic features and clinical outcome of central neurocytoma: analysis of 15 cases.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Central Neurocytoma of the Lateral Ventricle Presenting with Chronic Headache: A Case Report of a Rare Intraventricular Tumor.International medical case reports journal · 2026Article
- Article
- Whole Exome Sequencing Identifies PHF14 Mutations in Neurocytoma and Predicts Responsivity to the PDGFR Inhibitor Sunitinib.Biomedicines · 2022Article
- Central Neurocytoma with Hemorrhagic Presentation Case Report and Review of the Literature.Case reports in surgery · 2022Article
- Delving Inside the Enigmatic Central Neurocytoma: Electronic Hospital Database Retrieval.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2020Review
- The epidemiology of central and extraventricular neurocytoma in the United States between 2006 and 2014.Journal of neuro-oncology · 2019Article
- Primary central neurocytoma of the mesencephalic tectum in a pediatric patient.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Unique Case of Atypical Central Neurocytoma with Craniospinal Metastases and Pituitary Adenoma.Asian journal of neurosurgeryArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo get better recognition of central neurocytoma and diminish misdiagnosis.
methodsA retrospective review identified 15 cases of central neurocytoma. All cases of central neurocytoma were analyzed for their clinical symptoms, pathologic changes, immunohistochemical staining, prognosis and differential diagnosis. Clinical follow up was performed.
resultsThere were 8 males and 7 females aged 10-64 years (median 32.93 years). The most common presenting symptoms were those related to increased intracranial pressure (ICP), including headache (100%), papilledema (93%) and vomiting (80%). All tumors were located in the ventricular system. The tumors were composed of uniform cells with round nuclei and a fine chromatin pattern, and in some areas, small cells with perinuclear halo could be seen. In particular, the anuclear areas may have a fine fibrillary matrix (neuropil). Nuclear atypia and vascular proliferation appeared in two cases, respectively. Focal necrosis could be seen in one case. Immunohistochemical findings included expression of synaptophysin (15/15), neuron specific enolase (12/15) and glial fibrillary acidic protein (GFAP) (3/15). MIB-1 proliferation index ranged from 0.8-12.5%, and was more than 2% in 3 of 15 cases assessed. Follow-up information of 11 patients was available.
conclusionsCentral neurocytoma has a favorable prognosis in general, but in some cases, the clinical course could be aggressive. Increase of GFAP positivity, proliferation index and vascular proliferation might suggest a more malignant process.
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