ArticlePloS one2013
A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folate.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Epigenetics and human obesity.International journal of obesity (2005) · 2015Pooled it
- LINE-1 methylation levels, a biomarker of weight loss in obese subjects, are influenced by dietary antioxidant capacity.Redox report : communications in free radical research · 2016Trial
- Dietary modifications, weight loss, and changes in metabolic markers affect global DNA methylation in Hispanic, African American, and Afro-Caribbean breast cancer survivors.The Journal of nutrition · 2015Trial
- No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women.Obesity (Silver Spring, Md.) · 2014Trial
- The therapeutic potential of transposable element activity modulation.EMBO molecular medicine · 2026Review
- Changes in methylation associated with development of metabolic syndrome in testicular cancer patients treated with cisplatin chemotherapy.Scientific reports · 2025Article
- Retrotransposons and Diabetes Mellitus.Epigenomes · 2024Review
- Bone mineral density and normal-weight obesity syndrome: beyond body weight and body mass index.Journal of bone and mineral metabolism · 2023Article
- Serum folate concentration and health-related quality of life among the elderly in South Korea.Health and quality of life outcomes · 2021Article
- Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study.Nutrition journal · 2020Article
- Ethnic and Adipose Depot Specific Associations Between DNA Methylation and Metabolic Risk.Frontiers in genetics · 2020Article
- Overweight & obese Australian adults and micronutrient deficiency.BMC nutrition · 2020Article
- Dietary Folate Intake Is Negatively Associated with Excess Body Weight in Brazilian Graduates and Postgraduates (CUME Project).Nutrients · 2019Article
- Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population.Journal of atherosclerosis and thrombosis · 2018Article
- Defective regulation of L1 endogenous retroelements in primary Sjogren's syndrome and systemic lupus erythematosus: Role of methylating enzymes.Journal of autoimmunity · 2018Article
- LINE-1 methylation is positively associated with healthier lifestyle but inversely related to body fat mass in healthy young individuals.Epigenetics · 2016Article
- DNA methylation, insulin resistance and second-generation antipsychotics in bipolar disorder.Epigenomics · 2015Article
- Article
- Decreased global DNA methylation in the white blood cells of high fat diet fed vervet monkeys (Chlorocebus aethiops).Journal of physiology and biochemistry · 2014Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIdentification of associations between global DNA methylation and excess body weight (EBW) and related diseases and their modifying factors are an unmet research need that may lead to decreasing DNA methylation-associated disease risks in humans. The purpose of the current study was to evaluate the following; 1) Association between the degree of peripheral blood mononuclear cell (PBMC) L1 methylation and folate, and indicators of EBW, 2) Association between the degree of PBMC L1 methylation and folate, and insulin resistance (IR) as indicated by a higher homeostasis model assessment (HOMA-IR).
methodsThe study population consisted of 470 child-bearing age women diagnosed with abnormal pap. The degree of PBMC L1 methylation was assessed by pyrosequencing. Logistic regression models specified indicators of EBW (body mass index-BMI, body fat-BF and waist circumference-WC) or HOMA-IR as dependent variables and the degree of PBMC L1 methylation and circulating concentrations of folate as the independent predictor of primary interest.
resultsWomen with a lower degree of PBMC L1 methylation and lower plasma folate concentrations were significantly more likely to have higher BMI, % BF or WC (OR = 2.49, 95% CI:1.41-4.47, P = 0.002; OR = 2.49, 95% CI:1.40-4.51, P = 0.002 and OR = 1.98, 95% = 1.14-3.48 P = 0.0145, respectively) and higher HOMA-IR (OR = 1.78, 95% CI:1.02-3.13, P = 0.041).
conclusionOur results demonstrated that a lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR, especially in the presence of lower concentrations of plasma folate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.