ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2012
Overexpression of Gli1 in cancer interstitial tissues predicts early relapse after radical operation of breast cancer.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Prognostic role of Gli1 expression in solid malignancies: a meta-analysis.Scientific reports · 2016Pooled it
- WW45 inhibits breast cancer cell proliferation by the Hedgehog signaling pathway.American journal of translational research · 2021Article
- Article
- Tamoxifen Resistance: Emerging Molecular Targets.International journal of molecular sciences · 2016Review
- Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling.International journal of molecular sciences · 2016Article
- Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1.Molecular oncology · 2014Article
- Expression of Gli1 in the hedgehog signaling pathway and breast cancer recurrence.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2012Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether Gli1 expression is important in relapse after radical operation of breast cancer.
methodsUsing immunohistochemistry, Gli1 expression was analyzed in human primary breast cancer (n=284) and paracancerous tissues (n=20), and also in local lymph nodes (n=28) and metastatic lymph nodes (n=28).
resultsInitial analysis of Gli1 expression in a small cohort of 20 breast tumors and their paracancerous tissues showed a tendency towards Gli1 overexpression in breast cancer tissues (P<0.001). Further, Gli1 expression in 284 breast cancer tissue samples was analyzed and a significant correlation was found between increased expression of nuclear Gli1 and unfavorable recurrence-free survival (RFS) (P<0.05). The nuclear expression of Gli1 in metastatic lymph nodes following relapse after radical operation was much higher than that in the local lymph nodes of primary carcinoma (P<0.05). Most interestingly, the expression of Gli1 was much higher in the interstitial tissues of the relapsed group than of the non-relapsed group (P<0.001).
conclusionsBreast cancer shows a high prevalence of Gli1 expression, which is significantly correlated with aggressive features and unfavorable RFS. Nuclear Gli1 overexpression, especially in the interstitial tissues, signified early relapse after radical operation of breast cancer.
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