SynthesisPloS one2013
The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
121 citing papers in PubMed, 10 syntheses or guidelines pooled it, 306 citations in OpenAlex.
- Pooled it
- Candidate gene polymorphisms and power athlete status: a meta-analytical approach.Journal of physiology and biochemistry · 2025Pooled it
- Role of theInternational journal of environmental research and public health · 2024Pooled it
- Meta-analysis of genomic variants in power and endurance sports to decode the impact of genomics on athletic performance and success.Human genomics · 2024Pooled it
- A Systematic Review and Meta-analysis of the Association Between ACTN3 R577X Genotypes and Performance in Endurance Versus Power Athletes and Non-athletes.Sports medicine - open · 2024Pooled it
- Association between ACTN3 R577X genotype and risk of non-contact injury in trained athletes: A systematic review.Journal of sport and health science · 2023Pooled it
- Genetics of long-distance runners and road cyclists-A systematic review with meta-analysis.Scandinavian journal of medicine & science in sports · 2022Pooled it
- Genes and Elite Marathon Running Performance: A Systematic Review.Journal of sports science & medicine · 2019Pooled it
- Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis.PloS one · 2019Pooled it
- The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance.American journal of human genetics · 2018Pooled it
- Effect of angiotensin-converting enzyme inhibition on cardiovascular adaptation to exercise training.Physiological reports · 2022Trial
- Article
- From Athletic Performance to Functional Ageing: Shared Genetic Architecture, Redox-Inflammatory Pathways and Functional Reserve Across the Life Course-A Narrative Review.Biomedicines · 2026Review
- Nutrigenetic Markers Related to Nutrient Metabolism, Recovery, and Performance in Athletes: a Review of Current Evidence.Current nutrition reports · 2026Review
- Epigenetic Modulation of the ACE System Underlies the Slow Aerobic Muscle Phenotype and Metabolic Exercise Response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Review
- The VISA-C Questionnaire: A Self-Administered Assessment to Measure Finger/Hand/Wrist Pain in Climbers.Sports medicine - open · 2025Article
- TheSports (Basel, Switzerland) · 2025Article
- On the aspiration to decode the impact of genomics on performance in power and endurance sports.Human genomics · 2025Article
- Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic polymorphism is suggested to be associated with human physical performance. The angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism and the α-actinin-3 gene (ACTN3) R577X polymorphism have been most widely studied for such association analysis. However, the findings are frequently heterogeneous. We aim to summarize the associations of ACE I/D and ACTN3 R577X with sport performance by means of meta-analysis.
methodsWe systematically reviewed and quantitatively summarized published studies, until October 31, 2012, on relationship between ACE/ACTN3 genetic polymorphisms and sports performance, respectively.
resultsA total of 366 articles on ACE and 88 articles on ACTN3 were achieved by literature search. A significant association was found for ACE II genotype compared to D allele carriage (DD+ID) with increased possibility of physical performance (OR, 1.23; 95% CI, 1.05-1.45). With respect to sport discipline, the II genotype was found to be associated with performance in endurance athletes (OR, 1.35; 95% CI, 1.17-1.55). On the other hand, no significant association was observed for ACTN3 RR genotype as compared to X allele carriage (XX+RX) (OR, 1.03; 95% CI, 0.92-1.15). However, when restricted the analyses to power events, a significant association was observed (OR, 1.21; 95% CI, 1.03-1.42).
conclusionOur results provide more solid evidence for the associations between ACE II genotype and endurance events and between ACTN3 R allele and power events. The findings suggest that the genetic profiles might influence human physical performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.