Trial reportThe American journal of tropical medicine and hygiene2013
Inter-relationships of cardinal features and outcomes of symptomatic pediatric Plasmodium falciparum MALARIA in 1,933 children in Kampala, Uganda.
Trial report in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00707200 (Clinical Outcomes in Pediatric Plasmodium Falciparum Malaria According to Host Cytoadherence Factors), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Outcomes in Pediatric Plasmodium Falciparum Malaria According to Host Cytoadherence Factors
Who cites it
24 citing papers in PubMed.
- Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness.BMC medicine · 2015Trial
- The effect of blood storage age on treatment of lactic acidosis by transfusion in children with severe malarial anaemia: a pilot, randomized, controlled trial.Malaria journal · 2013Trial
- The role of the spleen in red blood cell loss caused by malaria: A mathematical model.PLoS computational biology · 2026Article
- The Association Between Malaria Parasite Geometrical Mean and Clinical Spectrum of Severe Disease in a High-Transmission Setting in Eastern Uganda: A Cross-Sectional Study.Journal of parasitology research · 2025Article
- Retention of uninfected red blood cells causing congestive splenomegaly is the major mechanism of anemia in malaria.American journal of hematology · 2024Article
- Practice patterns in pediatric infectious encephalopathy in four centers in Africa.Frontiers in pediatrics · 2024Article
- Severe malaria burden, clinical spectrum and outcomes at Apac district hospital, Uganda: a retrospective study of routine health facility-based data.Malaria journal · 2023Article
- Estimating the burden of severe malarial anaemia and access to hospital care in East Africa.Nature communications · 2023Article
- Genetic variations in human ATP2B4 gene alter Plasmodium falciparum in vitro growth in RBCs from Gambian adults.Malaria journal · 2023Article
- Whole Blood Transfusion for Severe Malarial Anemia in a High Plasmodium falciparum Transmission Setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Alteration of Blood Lactate Levels in Severe Falciparum Malaria: A Systematic Review and Meta-Analysis.Biology · 2021Review
- The clinical spectrum of severe childhood malaria in Eastern Uganda.Malaria journal · 2020Article
- Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study.Malaria journal · 2018Article
- Anemia was an Uncommon Complication of Severe Malaria in a High-Transmission Rural Area of Western Uganda.The American journal of tropical medicine and hygiene · 2018Observational
- Article
- Use of a Dual-Antigen Rapid Diagnostic Test to Screen Children for Severe Plasmodium falciparum Malaria in a High-Transmission, Resource-Limited Setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Observational
- Epidemiological and clinical profile of paediatric malaria: a cross sectional study performed on febrile children in five epidemiological strata of malaria in Cameroon.BMC infectious diseases · 2017Article
- Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia.Interdisciplinary perspectives on infectious diseases · 2017Article
- Severe imported malaria in children in France. A national retrospective study from 1996 to 2005.PloS one · 2017Article
- Young Sprague Dawley rats infected by Plasmodium berghei: A relevant experimental model to study cerebral malaria.PloS one · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria remains a challenging diagnosis with variable clinical presentation and a wide spectrum of disease severity. Using a structured case report form, we prospectively assessed 1,933 children at Mulago Hospital in Kampala, Uganda with acute Plasmodium falciparum malaria. Children with uncomplicated malaria significantly differed from those with severe disease for 17 features. Among 855 children with severe disease, the case-fatality rate increased as the number of severity features increased. Logistic regression identified five factors independently associated with death: cerebral malaria, hypoxia, severe thrombocytopenia, leukocytosis, and lactic acidosis. Cluster analysis identified two groups: one combining anemia, splenomegaly, and leukocytosis; and a second group centered on death, severe thrombocytopenia, and lactic acidosis, which included cerebral malaria, hypoxia, hypoglycemia, and hyper-parasitemia. Our report updates previous clinical descriptions of severe malaria, quantifies significant clinical and laboratory inter-relationships, and will assist clinicians treating malaria and those planning or assessing future research (NCT00707200) (www.clinicaltrials.gov).
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