ArticleMolecular & cellular proteomics : MCP2013
Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected.
Article in Molecular & cellular proteomics : MCP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
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- New analysis pipeline for high-throughput domain-peptide affinity experiments improves SH2 interaction data.The Journal of biological chemistry · 2020Article
- The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein.The Journal of biological chemistry · 2019Article
- Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor.PLoS computational biology · 2019Article
- Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks.Science signaling · 2018Article
- Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling.Cell reports · 2018Article
- Salinity-Induced Palmella Formation Mechanism in Halotolerant AlgaeFrontiers in plant science · 2017Article
- Exploiting receptor tyrosine kinase co-activation for cancer therapy.Drug discovery today · 2017Review
- Novel genetic risk variants for pediatric celiac disease.Human genomics · 2016Article
- Article
- Stimulus-Dependent Inhibitor of Apoptosis Protein Expression Prolongs the Duration of B Cell Signalling.Scientific reports · 2016Article
- Use of mechanistic models to integrate and analyze multiple proteomic datasets.Biophysical journal · 2015Article
- Phospho-tyrosine dependent protein-protein interaction network.Molecular systems biology · 2015Article
- A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.Nature genetics · 2014Article
- Integrating phosphoproteomics in systems biology.Computational and structural biotechnology journal · 2014Review
- Molecular dynamic simulation to explore the molecular basis of Btk-PH domain interaction with Ins(1,3,4,5)P4.TheScientificWorldJournal · 2013Article
- Rule-based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Mutation and overexpression of receptor tyrosine kinases or the proteins they regulate serve as oncogenic drivers in diverse cancers. To better understand receptor tyrosine kinase signaling and its link to oncogenesis, we used protein microarrays to systematically and quantitatively measure interactions between virtually every SH2 or PTB domain encoded in the human genome and all known sites of tyrosine phosphorylation on 40 receptor tyrosine kinases and on most of the SH2 and PTB domain-containing adaptor proteins. We found that adaptor proteins, like RTKs, have many high affinity bindings sites for other adaptor proteins. In addition, proteins that drive cancer, including both receptors and adaptor proteins, tend to be much more highly interconnected via networks of SH2 and PTB domain-mediated interactions than nononcogenic proteins. Our results suggest that network topological properties such as connectivity can be used to prioritize new drug targets in this well-studied family of signaling proteins.
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Registered trials
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